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4-acetamido-3-(trifluoromethyl)phenyl acetate is a chemical compound with the molecular formula C11H10F3NO3. It is a derivative of phenyl acetate, featuring a trifluoromethyl group at the 3-position and an acetamido group at the 4-position. 4-acetamido-3-(trifluoromethyl)phenyl acetate is known for its potential applications in the synthesis of pharmaceuticals and agrochemicals, particularly as an intermediate in the production of certain active ingredients. Its structure provides it with unique properties, such as increased lipophilicity due to the presence of the trifluoromethyl group, which can enhance its biological activity and membrane penetration. The acetate group further modifies its reactivity and solubility, making it a versatile building block in organic synthesis.

346-29-2

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346-29-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 346-29-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,4 and 6 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 346-29:
(5*3)+(4*4)+(3*6)+(2*2)+(1*9)=62
62 % 10 = 2
So 346-29-2 is a valid CAS Registry Number.

346-29-2Downstream Products

346-29-2Relevant academic research and scientific papers

Palladium-catalyzed trifluoromethylation of aromatic C-H bond directed by an acetamino group

Zhang, Li-Sheng,Chen, Kang,Chen, Guihua,Li, Bi-Jie,Luo, Shuang,Guo, Qing-Yun,Wei, Jiang-Bo,Shi, Zhang-Jie

supporting information, p. 10 - 13 (2013/04/10)

The first palladium-catalyzed ortho-trifluoromethylation of the aromatic C-H bond directed by an acetamino group is reported. This method provides an efficient and green approach to synthesize the highly biological potential key structure of ortho-CF3 acetanilides and anilines.

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