85624-06-2

Upstream product

• 5285-87-0 phenyl thiocyanate 
• 123-11-5 4-methoxy-benzaldehyde 
• 104-47-2 p-methoxybenzylnitrile 
• 882-33-7 diphenyldisulfane 
• 62-53-3 aniline 
• 104-93-8 p-methylanizole 
• 1195-98-8 2-methyl-2-phenylpropionitrile 

Downstream Products

• 16483-38-8 4-Dimethylamino-2-(4-methoxy-phenyl)-butyronitrile 
• 34603-52-6 1-[2-(dimethylamino)ethyl]-4'-methoxy-2,3-dihydro-[1,1′-biphenyl]-4(1H)-one 
• 85624-08-4 2-(2-Dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-(2-methyl-[1,3]dioxolan-2-yl)-butyronitrile 
• 85624-07-3 4-Dimethylamino-2-(4-methoxy-phenyl)-2-phenylsulfanyl-butyronitrile 

Relevant academic research and scientific papers

Synthesis of Nitrile-Bearing Quaternary Centers by an Equilibrium-Driven Transnitrilation and Anion-Relay Strategy

The efficient preparation of nitrile-containing building blocks is of interest due to their utility as synthetic intermediates and their prevalence in pharmaceuticals. As a result, significant efforts have been made to develop methods to access these motifs which rely on safer and non-toxic sources of CN. Herein, we report that 2-methyl-2-phenylpropanenitrile is an efficient, non-toxic, electrophilic CN source for the synthesis of nitrile-bearing quaternary centers by a thermodynamic transnitrilation and anion-relay strategy. This one-pot process leads to nitrile products resulting from the gem-difunctionalization of alkyl lithium reagents.

Odorless diphenyl diselenide and disulfide: Syntheses and applications

Bis[4-(trimethylsilyl)phenyl]diselenide (3) and bis[4-(trimethylsilyl) phenyl]disulfide (31) are found to be odorless equivalents of the commonly used diphenyl diselenide and diphenyl disulfide, respectively. The diselenide 3 is shown to be useful in the preparation of odorless selenium(II) chloride 26 and selenium(IV) trichloride 28 that follow similar reactivity patterns to their phenyl derivatives and can be stored refrigerated under dry conditions. The corresponding selenium(II) bromide had to be prepared fresh from 3 before use. It is also shown that the trimethylsilyl group in the sulfide products can be protodesilylated quantitatively using TFA. Georg Thieme Verlag Stuttgart.

Reaction of Aryl Aldehydes with Thiocyanates in the Presence of Tributylphosphine

Aryl aldehydes react with methyl thiocyanate in the presence of tributylphosphine to afford S-methyl thiobenzoates and arylacetonitriles in good yields.This is a novel disproportionation reaction involving carbon-carbon bond formation.These compounds thus obtained are easily converted into deoxybenzoins using sodium hydride.On the other hand, p-dialkylaminobenzaldehydes react with methyl thiocyanate under the same conditions to furnish both the corresponding trans-dicyanostilbenes and succinonitriles in moderate yields.Finally, the reaction was carried out with aryl thiocyanates resulting in the formation of addition products.