3463-02-3

Basic information

• Product Name: 4-(ETHYLTHIO)ANILINE
• Synonyms: 4-(ETHYLTHIO)ANILINE;UKRORGSYN-BB BBV-113297;4-(ethylthio)aniline(SALTDATA: HCl);[4-(ethylthio)phenyl]amine
• CAS NO: 3463-02-3
• Molecular Formula: C₈H₁₁NS
• Molecular Weight: 153.24
• Mol File: 3463-02-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 286.5°C at 760 mmHg
• Flash Point: 127.1°C
• Appearance: /
• Density: 1.09g/cm³
• Vapor Pressure: 0.00263mmHg at 25°C
• Refractive Index: 1.594
• CAS DataBase Reference: 4-(ETHYLTHIO)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(ETHYLTHIO)ANILINE(3463-02-3)
• EPA Substance Registry System: 4-(ETHYLTHIO)ANILINE(3463-02-3)

Safety Data

• Hazardous Substances Data: 3463-02-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H11NS/c1-2-10-8-5-3-7(9)4-6-8/h3-6H,2,9H2,1H3

Upstream product

• 7205-60-9 1-(ethylsulfanyl)-4-nitrobenzene 
• 861551-20-4 N,N'-bis-(4-ethylsulfanyl-phenyl)-hydrazine 
• 624-89-5 Ethyl methyl sulfide 
• 622-37-7 Phenyl azide 
• 352-93-2 diethyl sulphide 
• 14290-92-7 2-(ethylthio)-2-methyl-propane 
• 762-04-9 phosphonic acid diethyl ester 
• 1193-02-8 4-aminotiophenol 
• 80-40-0 ethyl ester of p-toluenesulfonic acid 
• 75-08-1 ethanethiol 
• 540-37-4 p-aminoiodobenzene 
• 722-27-0 bis(4-aminophenyl)disulfide 
• 93-89-0 benzoic acid ethyl ester 
• 824-78-2 4-nitrophenol sodium salt 

Downstream Products

• 59000-26-9 (4-ethylsulfanyl-phenyl)-urea 
• 71680-90-5 (4-ethylsulfanyl-phenyl)-thiourea 
• 86047-01-0 Ethyl 4-cyanophenyl sulfide 
• 69387-03-7 (4-ethylsulfanyl-phenyl)-phosphonic acid 
• 100133-95-7 1-(4-ethylsulfanyl-phenyl)-biguanide 
• 101587-73-9 N-(4-ethoxy-phenyl)-N'-(4-ethylsulfanyl-phenyl)-thiourea 
• 859735-79-8 N'-(4-ethylsulfanyl-phenyl)-N,N-dimethyl-thiourea 
• 105396-78-9 2-(t-BOC)amino-N-[4-(ethylthio)phenyl]acetamide 
• 1054579-87-1 4-(ethylsulfinyl)aniline 
• 1054579-45-1 N-(4-(ethylthio)phenyl)-6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-5-nitropyrimidin-4-amine 
• 57947-06-5 N-(4-Ethanesulfonyl-phenyl)-C,C,C-trifluoro-methanesulfonamide 
• 15863-42-0 1-ethylsulfanyl-4-isothiocyanato-benzene 
• 57946-81-3 N-(4-Ethylsulfanyl-phenyl)-C,C,C-trifluoro-methanesulfonamide 
• 28010-82-4 2-chloro-N-(4-ethylsulfanyl-phenyl)-acetamide 

Relevant articles and documents

Production of Alkyl Aryl Sulfides from Aromatic Disulfides and Alkyl Carboxylates via a Disilathiane–Disulfide Interchange Reaction

The results of this study show that disilathiane is an effective mediator in the synthesis of alkyl aryl sulfides with disulfides and alkyl carboxylates. Mechanistic studies suggest that disilathiane promotes cleavage of the sulfur–sulfur bond of disulfides to generate thiosilane as a key intermediate. Diselenides were also applicable to this transformation to produce the corresponding selenides.

The influence of electronic perturbations on the Sulfur-Fluorine Gauche Effect Dedicated to Prof. Dr. Antonio Togni on the occasion of his 60th birthday.

Herein, a solution phase NMR conformer population analysis is employed to probe the effect of remote electronic perturbations on the conformational equilibria of a series of para-substituted β-fluorosulfides (1), sulfoxides (2) and sulfone derivatives (3). Conformations that allow for stabilizing stereoelectronic (σC-H → σ?C-F) and electrostatic (Fδ-...Sδ+) interactions predominate: this is consistent with the Sulfur-Fluorine Gauche Effect. The molar fractions (χ) of the two possible gauche conformers correlate linearly with the electron-withdrawing aptitude of the para-substituent, rendering the system ideally suited for a Hammett-type analysis. Despite the clear influence that the remote para-substituents have on conformer population, this is superseded by the oxidation state on sulfur (II, IV, VI), where an increased preference for the gauche conformer follows the trend: sulfide sulfone sulfoxide. It is envisaged that this proof of concept in controlling conformer population, either by proximal (oxidation state) or remote tuning (para-substituent), will find application in molecular design.

Alkylthio Aromatic Amines

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