3463-03-4

Basic information

• Product Name: 3-(methylsulfanyl)benzenol
• Synonyms: 3-(methylsulfanyl)benzenol;3-(methylsulfanyl)phenol
• CAS NO: 3463-03-4
• Molecular Formula: C₇H₈OS
• Molecular Weight: 140.21
• Mol File: 3463-03-4.mol

Chemical Properties

• Boiling Point: 105-108°/2mm
• Appearance: /
• Density: 1.19±0.1 g/cm3(Predicted)
• PKA: 9.47±0.10(Predicted)
• CAS DataBase Reference: 3-(methylsulfanyl)benzenol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(methylsulfanyl)benzenol(3463-03-4)
• EPA Substance Registry System: 3-(methylsulfanyl)benzenol(3463-03-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 3463-03-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-(Methylsulfanyl)benzenol is used as an intermediate compound for the synthesis of formimidamidine derivatives, which are known for their potential use against phytopathogenic microorganisms. These derivatives can be employed as active ingredients in the development of new drugs or treatments targeting plant diseases caused by harmful microorganisms.
Used in Chemical Synthesis:
In the field of organic chemistry, 3-(methylsulfanyl)benzenol serves as a valuable building block for the synthesis of various organic compounds. Its unique structure allows for further functionalization and modification, making it a useful starting material for the development of new molecules with potential applications in various industries, such as pharmaceuticals, agrochemicals, and materials science.
Used in Research and Development:
3-(Methylsulfanyl)benzenol is also utilized in research and development laboratories for the study of its chemical properties and reactivity. Understanding the behavior of this compound can lead to the discovery of new synthetic routes and the development of novel compounds with specific applications in various fields.

Upstream product

• 2388-74-1 1-methoxy-3-methylsulfanyl-benzene 
• 1783-81-9 3-methylmercaptoaniline 
• 36282-40-3 (3-methoxyphenyl)magnesium bromide 
• 108-47-4 2,4-lutidine 
• 624-92-0 Dimethyldisulphide 
• 591-20-8 3-Bromophenol 
• 12775-96-1 copper 
• 33733-73-2 3-bromo-1-(methylthio)benzene 
• 111762-35-7 (3-(methylthio)phenyl)magnesium bromide 
• 40248-84-8 3-mercaptophenol 
• 74-88-4 methyl iodide 

Downstream Products

• 103262-80-2 1-acetoxy-3-methylsulfanyl-benzene 
• 17067-42-4 methanesulfonic acid-(3-methylsulfanyl-phenyl ester) 
• 106590-65-2 3,5-dinitro-benzoic acid-(3-methylsulfanyl-phenyl ester) 
• 67127-67-7 2-hydroxy-4-(methylthio)benzoic acid 
• 861076-84-8 2,4-dibromo-5-methylsulfanyl-phenol 
• 95420-73-8 2-hydroxy-4-(methylthio)benzoic acid methyl ester 
• 95420-74-9 4-(methylthio)-2-n-propoxybenzoic acid methyl ester 
• 95420-75-0 4-(methylthio)-2-n-propoxybenzoic acid 
• 89075-29-6 2-(4-Methylsulfanyl-2-propoxy-phenyl)-3H-imidazo[4,5-c]pyridine 
• 89075-36-5 2-(4-Methanesulfinyl-2-propoxy-phenyl)-3H-imidazo[4,5-c]pyridine 
• 791-28-6 Triphenylphosphine oxide 
• 837377-10-3 2-(3-methylsulfanyl-phenoxy)-nicotinic acid methyl ester 
• 93175-16-7 1-(2-hydroxy-4-(methylthio)phenyl)ethan-1-one 
• 1608150-55-5 3'-acetyl-2'-hydroxy-4'-methylthio-acetophenone 

Relevant articles and documents

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The present invention relates to a compound capable of effectively antagonizing EP4, which is a compound represented by formula I, or a tautomer, a stereoisomer, a hydrate, a solvate, a pharmaceutically-acceptable salt or a prodrug of the compound represented by formula I. R1 is selected from -CH3, -CHF2, and -CF3; R2 is selected from C2-C6 alkyl, C3-C6 cycloalkyl, halogenated C2-C6 alkyl, and halogenated C3-C6 cycloalkyl; R3 is selected from hydrogen, halogen, C1-C2 alkyl, and fluorinated C1-C2 alkyl; R4 is selected from hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxy, halogenated C1-C6 alkyl, and halogenated C1-C6 alkoxy.

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ADDITIVE FOR IMPARTING ULTRAVIOLET ABSORBENCY AND/OR HIGH REFRACTIVE INDEX TO MATRIX, AND RESIN MEMBER USING SAME

Provided is an additive for imparting ultraviolet absorbency, or an additive for imparting a high refractive index, which has satisfactory compatibility with a resin serving as a matrix and can maintain high transparency even if added in high concentrations. Also provided is an additive with which the function of imparting both ultraviolet absorbency and a high refractive index can be realized by means of one kind of additive. This additive is represented by the following Formula (I): wherein at least one of R1a to R9a is a monovalent sulfur-containing group represented by the following Formula (i-1) or Formula (i-2): wherein R10a to R12a each represent a divalent hydrocarbon group or the like; and R13a represents a monovalent hydrocarbon group or the like.

Metal-Free Approach to Biaryls from Phenols and Aryl Sulfoxides by Temporarily Sulfur-Tethered Regioselective C-H/C-H Coupling

We have developed metal-free regiocontrolled dehydrogenative C-H/C-H cross-coupling of aryl sulfoxides with phenols by means of trifluoroacetic anhydride. Because the reaction would proceed through an interrupted Pummerer reaction followed by sulfonium-tethered [3,3]-sigmatropic rearrangement, the C-H/C-H coupling takes place exclusively between the ortho positions of both substrates. Various functional groups including carbonyl, halo, siloxy, and even boryl moieties are compatible. The biaryl products naturally possess hydroxy and sulfanyl groups, which allows the products to be useful synthetic intermediates, as evidenced by the syntheses of π-expanded heteroarenes such as unprecedented 7,12-dioxa[8]helicene.

Synthetic strategies to 2′-hydroxy-4′- methylsulfonylacetophenone, a key compound for the preparation of flavonoid derivatives

Different strategies for the synthesis of 2′-hydroxy-4′- methylsulfonylacetophenone are reported in the present paper. This compound is considered as a key synthon for the synthesis of new flavonoid derivatives designed as potential cyclooxygenase-2 inhibitors. The retrosynthetic approach via 3′-methylsulfonylacetophenone, which included three synthetic pathways, did not allow us to obtain the expected compound. However, a synthesis from 3-mercaptophenol led to the desired acetophenone in three steps: thiophenol methylation, Friedel-Crafts acetylation and oxidation of the sulphide to the corresponding sulfone. The desired compound, 2′-hydroxy-4′- methylsulfonylacetophenone, will be used as a synthon for the preparation of novel flavonoid derivatives, such as 2′-hydroxychalcones, flavanones, flavones, and flavonols.

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Practical imidazole-based phosphine ligands for selective palladium-catalyzed hydroxylation of aryl halides

(Chemical Equation Presented) The phenol countdown: Novel imidazole-based phosphine ligands are synthesized on scales up to 100 g by a convenient lithiation-phosphorylation method. The phosphines are stable towards air and moisture and are successfully applied as ligands in the palladium-catalyzed selective hydroxylation of aryl halides (see scheme, dba=dibenzylideneacetone).

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NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS

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