34631-15-7

Upstream product

• 6566-57-0 1,3,5-tris(diethoxyphosphorylmethyl)benzene 
• 100-52-7 benzaldehyde 
• 100-42-5 styrene 
• 626-39-1 1,3,5-trisbromobenzene 
• 538-51-2 benzylidene phenylamine 
• 108-67-8 1,3,5-trimethyl-benzene 
• 72761-85-4 trans,trans-1,7-diphenyl-3,3,5,5-tetramethyl-3,5-disila-4-oxahepta-1,6-diene 

Downstream Products

• 76915-16-7 2,7-distyrylbis(3,4-diphenylcyclobutano<1,2-e,k>)-4,5,9,10-tetrahydropyrene 
• 27798-46-5 benzonaphtho<2,1-p>chrysene 
• 76900-48-6 5,6,14,15,20,21-Hexaphenylheptacyclo<8.8.4.1^3,17.1^8,12.0^4,7.0^13,16.0^19,22>tetracosa-1,3(23),8,10,12(24),17-hexaen 

Relevant academic research and scientific papers

Mono- and multifold C-C coupling reactions catalyzed by a palladium complex encapsulated in MIL-Cr as a three dimensional nano reactor

The organic palladium complex (trans-dichlorobis(4-iodoaniline-κN)palladium(ii)) was encapsulated into a porous metal-organic framework MIL-Cr (Pd complex@MIL-Cr) using ship-in-a-bottle strategy. The novel catalyst as a three dimensional nanoreactor was fully characterized using different techniques such as XRD, BET, XPS, SEM, EDX, TEM and ICP. The Pd complex@MIL-Cr is isostructural to the parent MIL-Cr framework, with a high surface area and pore volume of ca. 1418 m2 g-1 and 0.87 cm3 g-1, respectively. The nanoreactor was highly efficient in the catalytic conversion of aryl halides, showing extraordinarily higher activity than the homogeneous Pd counterparts. Surprisingly, high yields were achieved in Suzuki-Miyaura and Heck coupling reactions of chloroarenes bearing a wide range of substituents. Besides, this protocol could be extended to the cross-couplings of 2-bromo and 2,6-dibromopyridine with arylboronic acids in excellent yields at room temperature. The Pd complex@MIL-Cr was also used as an efficient and convenient catalyst for the preparation of a series of C3-symmetric molecules with benzene, pyridine or pyrimidine units as the central core. Moreover, the catalyst could be recovered easily and reused several times without any considerable loss of its catalytic activity. Investigation of the nature of the recovered catalyst showed that the catalyst is converted to Pd nanoparticles.

Polyaniline-anchored palladium catalyst-mediated Mizoroki-Heck and Suzuki-Miyauraa reactions and one-pot Wittig-Heck and Wittig-Suzuki reactions

A polyaniline-anchored palladium catalyst was prepared and screened for coupling reactions of aryl halides. The robust and recyclable catalyst was effective in Mizoroki-Heck and Suzuki-Miyaura reactions of aryl bromides and aryl iodides. The catalyst system was further employed for one-pot Wittig-Heck and Wittig-Suzuki combinations to build conjugated compounds in good conversions.

Palladium nanoparticles supported on triazine functionalised mesoporous covalent organic polymers as efficient catalysts for Mizoroki-Heck cross coupling reaction

A novel class of mesoporous covalent organic polymer (MCOP) was synthesised by the nucleophilic substitution of cyanuric chloride with 4,4′- dihydroxybiphenyl. The MCOP was fully characterized using powder X-ray diffraction analysis, Fourier transform infrared spectroscopy, 13C-solid state NMR spectroscopy, field emission scanning electron microscopy and thermogravimetric analysis. These nitrogen rich materials act as good supports for palladium nanoparticles (Pd NPs) and exhibit excellent catalytic activity towards Mizoroki-Heck cross coupling between aryl bromides and alkenes. Hot filtration tests demonstrate that the presence of the triazine rings on the polymers is beneficial for enhancing the stability of Pd NPs. The polymers are also cheap, easy to synthesise and can be recycled up to five times with only a minor loss of activity. the Partner Organisations 2014.

Palladium nanoparticles immobilized on nano-silica triazine dendritic polymer (Pdnp-nSTDP): An efficient and reusable catalyst for suzuki-miyaura cross-coupling and heck reactions

A new catalyst based on palladium nanoparticles immobilized on nano-silica triazine dendritic polymer (Pdnp-nSTDP) was synthesized and characterized by FT-IR spectroscopy, thermogravimetric analysis, field emission scanning electron microscopy, energy dispersive X-ray, transmission electron microscopy and elemental analysis. The size of the palladium nanoparticles was determined to be 3.1±0.5 nm. This catalytic system showed high activity in the Suzuki-Miyaura cross-coupling of aryl iodides, bromides and chlorides with arylboronic acids and also in the Heck reaction of these aryl halides with styrenes. These reactions were best performed in a dimethylformamide (DMF)/water mixture (1:3) in the presence of only 0.006 mol% and 0.01 mol% of the catalyst, respectively, under conventional conditions and microwave irradiation to afford the desired coupling products in high yields. The Pdnp-nSTDP was also used as an efficient catalyst for the preparation of a series of star- and banana-shaped compounds with a benzene, pyridine, pyrimidine or 1,3,5-triazine unit as the central core. Moreover, the catalyst could be recovered easily and reused several times without any considerable loss of its catalytic activity. Copyright

Inspiration from old dyes: Tris(stilbene) compounds as potent gram-positive antibacterial agents

Herein we describe the preparation and structure-activity relationship studies on range of stilbene based compounds and their antibacterial activity. Two related compounds, each bearing carboxylic acid moieties, exhibit good activity against several bacterial strains, including methicillin-resistant Staphylococcus aureus MRSA (ATCC 33592 and NCTC 10442). Compound 10 was most active against Moraxella catarrhalis with minimum inhibitory concentrations (MICs) of 0.12-0.25 μg mL-1 and against Staphylococcus spp. with MICs ranging from 2-4 μg mL-1. The derivative 17 showed increased activity with MICs of 0.06-0.25 μg mL-1 against M. catarrhalis and 0.12-1 against Staphylococcus spp. This level of activity is similar to that reported for S. aureus for antibiotics, such as vancomycin, with MICs of ≤2.0 μg mL-1 and clindamycin with MICs of ≤0.5 μg mL -1. As an indicator of toxicity, 17 was tested for its ability to lyse sheep erythrocytes, and showed low haemolytic activity. Such results highlight the value of tris(stilbene) compounds as antibacterial agents providing suitable properties for further development. Routes to new antibiotics: The preparation of and structure-activity relationship studies on a range of stilbene based compounds revealed two related compounds, each bearing carboxylic acid moieties, exhibiting pronounced activity against several bacterial strains including methicillin-resistant Staphylococcus aureus, MRSA (see scheme, dba = dibenzylidene acetone). Copyright

Application of 1-(α-aminobenzyl)-2-naphthols as air-stable ligands for pd-catalyzed Mizoroki-Heck coupling reaction

Air-stable, easily accessible Mannich bases, 1-(α-aminobenzyl)-2- naphthols, are used as ligands in palladium-catalyzed Mizoroki-Heck reaction on a variety of substrates. High turnover numbers are observed for both the reactions with aryl bromides and iodides, while aryl chlorides are inert. Copyright Taylor & Francis Group, LLC.

ANTIMICROBIAL COMPOUNDS

A compound for use as an antimicrobial having a formula (A).

A novel approach to stilbenoid dendrimer core synthesis

A new synthetic protocol for the one-pot, stereoselective synthesis of 1,3,5-tris[(E)-4-halostyryl]benzene and 1,2,4,5-tetrakis[(E)-4-halostyryl] benzene derivatives as stilbenoid dendrimer cores via palladium-catalyzed Hiyama cross-coupling of aryl trior tetrahalides with 1,3-bis[(E)-4-halostyryl] disiloxanes is described. Georg Thieme Verlag Stuttgart.