635-51-8

Basic information

• Product Name: DL-Phenylsuccinic acid
• Synonyms: ALPHA-PHENYLSUCCINIC ACID;AKOS BC-1259;2-PHENYLSUCCINIC ACID;D,L-2-PHENYLBUTANEDIOIC ACID;D,L-2-PHENYLSUCCINIC ACID;DL-PHENYLSUCCINIC ACID;(+/-)-PHENYLSUCCINIC ACID;PHENYLSUCCINIC ACID
• CAS NO: 635-51-8
• Molecular Formula: C₁₀H₁₀O₄
• Molecular Weight: 194.18
• EINECS: 211-238-1
• Product Categories: FINE Chemical & INTERMEDIATES;C10;Carbonyl Compounds;Carboxylic Acids;Building Blocks;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Organic Building Blocks
• Mol File: 635-51-8.mol
• Article Data: 25

Chemical Properties

• Melting Point: 166-168 °C(lit.)
• Boiling Point: 290.62°C (rough estimate)
• Flash Point: 154.2 °C
• Appearance: White cream/Crystalline Powder
• Density: 1.2534 (rough estimate)
• Vapor Pressure: 0.000306mmHg at 25°C
• Refractive Index: 1.5430 (estimate)
• Storage Temp.: Store below +30°C.
• PKA: pK1:3.78;pK2:5.55 (20°C)
• Stability: Combustible. Incompatible with strong oxidizing agents.
• BRN: 1875051
• CAS DataBase Reference: DL-Phenylsuccinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: DL-Phenylsuccinic acid(635-51-8)
• EPA Substance Registry System: DL-Phenylsuccinic acid(635-51-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25-37/39-26
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 635-51-8(Hazardous Substances Data)

Usage

Chemical Properties

light beige powder

Synthesis Reference(s)

Synthesis, p. 765, 1986 DOI: 10.1055/s-1986-31770

InChI:InChI=1/C10H10O4/c11-9(12)6-8(10(13)14)7-4-2-1-3-5-7/h1-5,8H,6H2,(H,11,12)(H,13,14)/p-2/t8-/m0/s1

Upstream product

• 493-72-1 5-phenyl-cyclohexane-1,3-dione 
• 13706-68-8 (+-)-phenylsuccinonitrile 
• 14387-18-9 3-cyano-3-phenyl propionic acid 
• 14025-83-3 3-cyano-3-phenylpropanoic acid ethyl ester 
• 68060-17-3 3-phenyl-1,5-heptadiene 
• 51367-64-7 3-chloro-5-phenylcyclohex-2-en-1-one 
• 854854-27-6 4-oxo-2,5-diphenylpentanoic acid 
• 41441-40-1 ethyl 3-phenyl-4-nitrobutanoate 
• 151-50-8 potassium cyanide 
• 100-52-7 benzaldehyde 
• 106-94-5 propyl bromide 
• 105-56-6 ethyl 2-cyanoacetate 
• 10034-85-2 hydrogen iodide 
• 7732-18-5 water 

Downstream Products

• 150508-16-0 3-phenyl-1-propyl-pyrrolidine-2,5-dione 
• 36122-35-7 2-phenylmaleic anhydride 
• 30952-65-9 2-hydroxy-2-phenylbutanedioic acid 
• 29427-69-8 3-oxoindan-1-carboxylic acid 
• 32676-72-5 phenylsuccinyl chloride 
• 21021-53-4 4-Nitrophenylsuccinic acid 
• 6332-94-1 (2-nitro-phenyl)-succinic acid 
• 1131-15-3 2-phenylsuccinic anhydride 
• 73923-85-0 1-(2-hydroxy-ethyl)-3-phenyl-pyrrolidine-2,5-dione 
• 54433-51-1 1-allyl-3-phenyl-pyrrolidine-2,5-dione 
• 855183-88-9 N,N'-phenylsuccinyl-bis-carbamic acid diethyl ester 
• 95162-02-0 3',6'-dihydroxy-4-phenyl-3,4-dihydro-spiro[furan-2,9'-xanthen]-5-one 
• 6837-05-4 (+/-)-2-phenyl-1,4-butanediol 
• 62-23-7 4-nitro-benzoic acid 

Relevant articles and documents

Photoredox Activation of Formate Salts: Hydrocarboxylation of Alkenes via Carboxyl Group Transfer

A photoredox activation mode of formate salts for carboxylation was developed. Using a formate salt as the reductant, carbonyl source, and hydrogen atom transfer reagent, a wide range of alkenes can be converted into acid products via a carboxyl group tra

Cu/PCy3-Catalyzed Formal Carbene Insertion into Electron-Deficient C?H Bonds

A carbene insertion into electron-deficient C?H bonds of 1,3-diesters, β-ketoesters, β-ketonitriles, and malononitriles was realized by using CuCN/PCy3 as the catalyst. The reaction provides a straightforward approach to the synthetically important multi-substituted succinic acid derivatives. A plausible reaction mechanism with cyclopropanation/ring opening as key steps was proposed based on control experiments.

Method for synthesizing succinic acid compounds

The invention provides a method for synthesizing succinic acid compounds. The method specifically comprises the following steps: adding a substrate, a photocatalyst and an alkali into a reaction tube,adding a reducing agent and a solvent under the atmosphere of CO2, conducting reacting under the irradiation of visible light, carrying out quenching treatment after the raw materials react completely, and then conducting separating and purifying to obtain a dicarboxylated product of olefin, namely a succinic acid compound. The photocatalyst is 4CzIPN or Ir[(ppy)2(dtbppy)]PF6 and the like, and the reaction substrate comprises 1,1-diaryl ethylene, a monoaryl substituted olefin compound, an acrylate compound and allene. According to the scheme provided by the invention, the reaction conditionsare mild, the applicability of the reaction substrate is wide, and the yield is basically not influenced under the condition that the reaction substrate is amplified to the gram scale; and meanwhile,the invention overcomes the defects of high toxicity of reagents and harsh reaction conditions in the prior art, and has a good industrial application prospect.