346417-71-8

Basic information

• Product Name: 2-(4-{(R)-2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-1-phenyl-ethyl}-piperazin-1-yl)-acetamide
• CAS NO: 346417-71-8
• Molecular Weight: 503.488
• Mol File: 346417-71-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-{(R)-2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-1-phenyl-ethyl}-piperazin-1-yl)-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-{(R)-2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-1-phenyl-ethyl}-piperazin-1-yl)-acetamide(346417-71-8)
• EPA Substance Registry System: 2-(4-{(R)-2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-1-phenyl-ethyl}-piperazin-1-yl)-acetamide(346417-71-8)

Safety Data

• Hazardous Substances Data: 346417-71-8(Hazardous Substances Data)

Upstream product

• 551943-88-5 1-{(R)-2-[1-(3,5-Bis-trifluoromethyl-phenyl)-vinyloxy]-1-phenyl-ethyl}-4-(toluene-4-sulfonyl)-piperazine 
• 551943-86-3 3,5-Bis-trifluoromethyl-benzoic acid (R)-2-phenyl-2-[4-(toluene-4-sulfonyl)-piperazin-1-yl]-ethyl ester 
• 551943-83-0 (R) 2-Phenyl-2-[4-(toluene-4-sulfonyl)-piperazin-1-yl]-ethanol 
• 725-89-3 3,5-bistrifluoromethylbenzoic acid 
• 683-57-8 bromo-acetic acid amide 
• 551943-93-2 1-{(R)-2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-1-phenyl-ethyl}-piperazine 

Relevant articles and documents

Discovery of orally bioavailable NK1 receptor antagonists

Benzyloxyphenethylpiperazines are a new class of high affinity NK1 receptor antagonists. Oral bioavailability and selectivity can be fine tuned by the nature of the substituents on the basic nitrogen atom. Addition of substituents with a carboxylic acid group led to very selective and orally active NK1 antagonists free of interaction with L-type calcium channels.