346424-35-9Relevant articles and documents
Discovery of novel aldose reductase inhibitors using a protein structure-based approach: 3D-database search followed by design and synthesis
Iwata,Arisawa,Hamada,Kita,Mizutani,Tomioka,Itai,Miyamoto
, p. 1718 - 1728 (2001)
Aldose reductase (AR) has been implicated in the etiology of diabetic complications. Due to the limited number of currently available drugs for the treatment of diabetic complications, we have carried out structure-based drug design and synthesis in an at