346630-03-3Relevant academic research and scientific papers
Suzuki-Miyaura Cross-Coupling with Quasi-Heterogeneous Palladium
Conlon, David A.,Pipik, Brenda,Ferdinand, Simone,LeBlond, Carl R.,Sowa Jr., John R.,Izzo, Bill,Collins, Paul,Ho, Guo-Jie,Williams, J. Michael,Shi, Yao-Jun,Sun, Yongkui
, p. 931 - 935 (2003)
The Suzuki-Miyaura cross-coupling reaction using heterogeneous Pd/C has a homogeneous component. The soluble palladium concentration increases during the reaction reaching a maximum at ca. 90% conversion before falling to 4 ppm.
Process development and large-scale synthesis of a PDE4 inhibitor
Conlon, David A.,Drahus-Paone, Antoinette,Ho, Guo-Jie,Pipik, Brenda,Helmy, Roy,McNamara, James M.,Shi, Yao-Jun,Williams, J. Michael,Macdonald, Dwight,Deschenes, Denis,Gallant, Michel,Mastracchio, Anthony,Roy, Bruno,Scheigetz, John
, p. 36 - 45 (2012/12/21)
An efficient, scalable synthesis of the PDE4 inhibitor, 6-[1-methyl-1-(methylsulfonyl)ethyl]-8-(3-{(E)-2-(3-methyl-1,2,4-oxadiazol-5-yl) -2-[4-(methylsulfonyl)phenyl]vinyl}phenyl)-quinoline benzenesulfonate (10) is described. The synthesis is highly conve
Substituted 8-arylquinoline phosphodiesterase-4 inhibitors
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, (2008/06/13)
Novel substituted 8-arylquinolines, wherein the aryl group at the 8-position contains a substituent substituted-alkenyl group, are PDE4 inhibitors.
Substituted 8-arylquinoline phosphodiesterase-4 inhibitors
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, (2008/06/13)
Novel sulfuric acid, methanesulfonic acid, p-toluenesulfonic acid, 2-naphthalenesulfonic acid, hydrochloride acid, or benzenesulfonic acid salts of substituted 8-arylquinolines, wherein the aryl group at the 8-position contains a substituent substituted-a
