346704-91-4

Upstream product

• 2965-22-2 methyl 2-fluoro-5-nitro-benzoate 
• 108-95-2 phenol 
• 6307-82-0 2-chloro-5-nitro-benzoic acid methyl ester 
• 346704-90-3 methyl 5-nitro-2-phenoxy-benzoate 

Downstream Products

• 1596360-97-2 methyl 5-(tert-butoxycarbonylamino)-2-phenoxy-benzoate 
• 1596360-81-4 9H-fluoren-9-ylmethyl N-[(5S)-5-[[6-[[3-(3-carbamoyl-4-phenoxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]methyl]-7-methyl-pyrrolo[2,3-d]pyrimidine-2-carbonyl]amino]-5-cyano-pentyl]carbamate 
• 1596360-38-1 N-[(1S)-5-amino-1-cyano-pentyl]-6-[[3-(3-carbamoyl-4-phenoxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]methyl]-7-methyl-pyrrolo[2,3-d]pyrimidine-2-carboxamide 
• 1596360-98-3 tert-butyl N-(3-carbamoyl-4-phenoxy-phenyl)carbamate 
• 1596360-99-4 ethyl 2-[(3-carbamoyl-4-phenoxy-phenyl)amino]acetate 
• 1596360-09-6 5-(2,4-dioxoimidazolidin-1-yl)-2-phenoxy-benzamide 
• 117821-54-2 5-Amino-2-phenoxy-benzamide 
• 1596360-58-5 methyl 6-[[3-(3-carbamoyl-4-phenoxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]methyl]-7-methyl-pyrrolo[2,3-d]pyrimidine-2-carboxylate 

Relevant academic research and scientific papers

Pyrrolopyrimidine-inhibitors with hydantoin moiety as spacer can explore P4/S4 interaction on plasmin

In the development of plasmin inhibitors, a novel chemotype, pyrrolopyrimidine scaffold possessing two motifs, a hydantoin-containing P4 moiety and a warhead-containing P1 moiety, is uncovered. A unique feature of the new line of the plasmin inhibitors is

Substituted N'-(arylcarbonyl)-benzhydrazides, N'-(arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof

The present invention is directed to substituted N′-(arylcarbonyl)-benzhydrazides, N′-(arylcarbonyl)-benzylidene-hydrazides and analogs thereof, represented by the Formulae I and II: wherein Ar1, Ar2, and R1-R2 are defined herein. The present invention also relates to the discovery that compounds having Formulae I and II are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.