3469-94-1Relevant academic research and scientific papers
N-nrylalkylpiperidines as high-affinity sigma-1 and sigma-2 receptor ligands: Phenylpropylamines as potential leads for selective sigma-2 agents
Maeda, Dean Y.,Williams, Wanda,Kim, Wes E.,Thatcher, Linn N.,Bowen, Wayne D.,Coop, Andrew
, p. 497 - 500 (2002)
To delineate the differences between the structural requirements necessary for recognition at sigma-1 and sigma-2 receptors, a range of phenethyl- and phenylpropylpiperidines were evaluated in binding assays. Phenethylpiperidines were found to favor sigma-1 receptors, whereas phenylpropylpiperidines tend to favor sigma-2 receptors. It appears that phenylpropylamine is a potential pharmacophore for selective sigma-2 ligands.
A potassium magnesiate complex: Synthesis, structure and catalytic intermolecular hydroamination of styrenes
Guan, Bing-Tao,Liu, Yu-Feng,Zhai, Dan-Dan,Zhang, Xiang-Yu
supporting information, (2022/01/19)
A new heterobimetallic potassium magnesiate complex KMg[N(SiMe3)2]2Bn (Bn = PhCH2-) was synthesized by simply mixing magnesium amide and potassium benzyl in toluene. The TMEDA-ligated potassium magnesiate comple
Hydroamination of terminal alkynes with secondary amines catalyzed by copper: Regioselective access to amines
Bahri, Janet,Blieck, Rémi,Jamoussi, Bassem,Taillefer, Marc,Monnier, Florian
, p. 11210 - 11212 (2015/07/07)
A simple and convenient copper-catalyzed hydroamination of arylacetylenes with secondary amines has been performed giving a simple access to aliphatic amines after reduction of the hydroaminated products (E-enamines). Here we described a mild catalytic system utilizing CuCN precatalyst without any additive ligands in a solvent-free system.
