34701-72-9Relevant academic research and scientific papers
One-Pot Green Synthesis of 2-Oxo-2H-chromene-3-carbonitriles Using Dual-Frequency Ultrasonication
Aruna,Kumar, S.,Sharma, S. P.,Vashisht, N.
, p. 1508 - 1512 (2021/10/26)
Abstract: A green synthesis of 2-oxo-2H-chromene-3-carbonitriles has been carried out in one step by reacting 2-hydroxybenzaldehydes or 2-hydroxyacetophenones with ethyl cyanoacetate under dual-frequency ultrasonica-tion (ultrasonic bath of 40 KHz and probe of 20 KHz). The compounds were obtained in very high yield, and their structures were confirmed by IR and NMR data.
Coumarin derivatives act as novel inhibitors of human dipeptidyl peptidase III: Combined in vitro and in silico study
?ubari?, Domagoj,Agi?, Dejan,Be?lo, Drago,Kara?i?, Zrinka,Karna?, Maja,Lisjak, Miroslav,Lon?ari?, Melita,Molnar, Maja,Popovi?, Boris M.,Rastija, Vesna,Tomi?, Sanja
, (2021/06/22)
Dipeptidyl peptidase III (DPP III), a zinc-dependent exopeptidase, is a member of the metalloproteinase family M49 with distribution detected in almost all forms of life. Although the physiological role of human DPP III (hDPP III) is not yet fully elucida
ZrCl4/[bmim]BF4-catalyzed condensation of salicylaldehydes and malononitrile: Single-step synthesis of 3-cyanocoumarin derivatives
Valizadeh, Hassan,Mahmoodian, Manzar,Gholipour, Hamid
experimental part, p. 799 - 802 (2011/09/16)
Figure represented. A versatile and efficient single-step route to 3-cyanocoumarins via Knoevenagel condensation of salicylaldehydes and malononitrile using ZrCl4 as the catalyst (15 mol %) in ionic liquid 1-(n-butyl)-3-methylimidazolium tetrafluoroborate as reaction medium and catalyst is described. The novel procedure features single step, short reaction time, good yields, and simple workup.
Facile, efficient, and eco-friendly synthesis of benzo[b] pyran-2-imines over MgO and transformation to the coumarin derivatives
Valizadeh, Hassan,Fakhari, Ashraf
scheme or table, p. 1392 - 1395 (2010/03/30)
(Chemical Equation Presented) Room temperature synthesis of benzo[b]pyran-2-imine derivatives via the Knoevenagel condensation of malononitrile and cyanoacetates with salicylaldehyde derivatives over MgO and their transformation to the known coumarins is described. The satisfactory results were obtained with good yields, short reaction time, and simplicity in the experimental procedure.
Synthesis of new iminocoumarins and their transformations into N-chloro and hydrazono compounds
Volmajer, Julija,Toplak, Renata,Leban, Ivan,Le Marechal, Alenka Majcen
, p. 7012 - 7021 (2007/10/03)
The Knoevenagel reaction between 2-hydroxybenzaldehydes and active methylene compounds (malononitrile and ethyl cyanoacetate) produces iminocoumarins and/or coumarins. In order to study the reactivity of the prepared iminocoumarins, chlorination and reaction with N-nucleophiles were studied.
One-Pot Synthesis of 3-Carboxycoumarins via Consecutive Knoevenagel and Pinner Reactions in Water
Fringuelli, Francesco,Piermatti, Oriana,Pizzo, Ferdinando
, p. 2331 - 2334 (2007/10/03)
Chloro-, hydroxy-, methoxy-, and tert-butyl-substituted 3-carboxycoumarins have been prepared by one-pot procedure by reaction of suitably substituted salicylaldehydes with malononitrile in water. The over-all yields are high and the protocol does not require organic solvents.
Novel N-chlorinated derivatives of 2H-1-benzopyran-2-imines
Volmajer, Julija,Toplak, Renata,Bittner, Shmuel,Leban, Ivan,Le Marechal, Alenka Majcen
, p. 2363 - 2366 (2007/10/03)
A series of new N-chlorobenzopyran-2-imines were prepared in moderate to good yields, by reacting sodium hypochlorite in an acidic medium with benzopyran-2-imines obtained via the Knoevenagel condensation. Some of the N-chlorobenzopyran-2-imines obtained are potential antiproliferating agents.
