56437-16-2

Basic information

• Product Name: 7-HYDROXYCOUMARIN-3-CARBOXYLICACID
• Synonyms: 7-HYDROXYCOUMARIN-3-CARBOXYLIC ACID;6-Hydroxy-2-oxo-2H-1-benzopyran-3-carboxylic acid;6-HYDROXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID;6-hydroxycoumarin-3-carboxylic acid
• CAS NO: 56437-16-2
• Molecular Formula: C₁₀H₆O₅
• Molecular Weight: 206.15
• Mol File: 56437-16-2.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-HYDROXYCOUMARIN-3-CARBOXYLICACID(CAS DataBase Reference)
• NIST Chemistry Reference: 7-HYDROXYCOUMARIN-3-CARBOXYLICACID(56437-16-2)
• EPA Substance Registry System: 7-HYDROXYCOUMARIN-3-CARBOXYLICACID(56437-16-2)

Safety Data

• Hazardous Substances Data: 56437-16-2(Hazardous Substances Data)

Usage

Description

7-Hydroxycoumarin-3-carboxylic acid, also known as umbelliferone, is an organic compound belonging to the coumarin family. It is a white crystalline substance with a molecular formula of C9H6O4. 7-HYDROXYCOUMARIN-3-CARBOXYLICACID exhibits strong fluorescence properties and is widely used in various applications due to its unique chemical and physical characteristics.

Uses

Used in Chemical Synthesis:
7-Hydroxycoumarin-3-carboxylic acid is used as a key intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. Its versatile chemical structure allows for easy functionalization and modification, making it a valuable building block in the development of new molecules with potential applications in different industries.
Used in Analytical Chemistry:
As a pH-indicator, 7-Hydroxycoumarin-3-carboxylic acid is used in the development of pH sensors. It can be immobilized on a support to create a sensor that can detect and measure the pH levels of various solutions. This application is particularly useful in environmental monitoring, quality control in the food and pharmaceutical industries, and research laboratories.
Used in Fluorescence-Based Assays:
Due to its strong fluorescence properties, 7-Hydroxycoumarin-3-carboxylic acid is employed in the development of fluorescence-based assays for detecting and quantifying various analytes, such as enzymes, proteins, and nucleic acids. These assays are widely used in research, diagnostics, and drug discovery.
Used in Drug Delivery Systems:
Similar to gallotannin, 7-Hydroxycoumarin-3-carboxylic acid can be incorporated into drug delivery systems to improve the bioavailability and therapeutic outcomes of various drugs. Its chemical properties allow for the development of novel carriers and formulations that can enhance the delivery of active pharmaceutical ingredients to target tissues and cells.

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 1194-98-5 2,5-Dihydroxybenzaldehyde 
• 70160-51-9 6-hydroxy-2-oxo-2H-chromene-3-carboxylic acid ethyl ester 
• 34701-72-9 6-hydroxy-2-oxo-2H-chromene-3-carbonitrile 
• 141-82-2 malonic acid 
• 303063-73-2 6-hydroxy-2-imino-2H-chromene-3-carbonitrile 

Downstream Products

• 1194-98-5 2,5-Dihydroxybenzaldehyde 

Relevant articles and documents

Method for synthesizing coumarin-3-carboxylic acid compounds by one-pot two-step method

The invention relates to a method for synthesizing coumarin-3-carboxylic acid compounds by a one-pot two-step method. The structural formula of the coumarin-3-carboxylic acid compounds is shown in the description, wherein R1 is H , Cl , Br, NO2 , CH3 and HO . According to the synthesis process of the coumarin-3-carboxylic acid compounds, malonic acid, acetone and substituted salicylaldehyde serve as raw materials, iodine serves as a catalyst, acetic anhydride serves as a solvent, a series of coumarin-3-carboxylic acid compounds are synthesized through a one-pot cascade reaction, and the efficiency and the yield are greatly improved compared with a fractional step method.

Design, Synthesis, and Molecular Modeling Studies of Novel Coumarin Carboxamide Derivatives as eEF-2K Inhibitors

Eukaryotic elongation factor-2 kinase (eEF-2K) is an unusual alpha kinase commonly upregulated in various human cancers, including breast, pancreatic, lung, and brain tumors. We have demonstrated that eEF-2K is relevant to poor prognosis and shorter patie

Synthesis and characterization of two novel biological-based nano organo solid acids with urea moiety and their catalytic applications in the synthesis of 4,4′-(arylmethylene)bis(1H-pyrazol-5-ol), coumarin-3-carboxylic acid and cinnamic acid derivatives under mild and green conditions

2-Carbamoylhydrazine-1-sulfonic acid and carbamoylsulfamic acid as novel, mild and biological-based nano organocatalysts with urea moiety were designed, synthesized and fully characterized by FT-IR, 1H NMR, 13C NMR, mass spectrometry, elemental analysis, thermal gravimetric, derivative thermal gravimetric, X-ray diffraction patterns, scanning electron microscopy, transmission electron microscopy, energy-dispersive X-ray spectroscopy, atomic force microscopy and UV/Vis analysis. The catalytic applications of 2-carbamoylhydrazine-1-sulfonic acid and carbamoylsulfamic acid were studied in the synthesis of 4,4′-(arylmethylene)bis(1H-pyrazol-5-ol), coumarin-3-carboxylic acid and cinnamic acid derivatives via the condensation reaction between several aromatic aldehydes and 1-phenyl-3-methylpyrazol-5-one (synthesis of 4,4′-(arylmethylene)bis(1H-pyrazol-5-ols)), the Knoevenagel condensation of Meldrum's acid with salicylaldehyde derivatives (synthesis of coumarin-3-carboxylic acids) and the condensation of Meldrum's acid with aromatic aldehydes (synthesis of cinnamic acids) under mild and solvent-free conditions. In the presented studies, some products were formed and reported for the first time. The described nano organo solid acids have potential in industry.