3471-08-7

Basic information

• Product Name: (-)-trans-2.3-Diphenyl-cyclopropancarbonsaeure
• CAS NO: 3471-08-7
• Molecular Weight: 238.286
• Mol File: 3471-08-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (-)-trans-2.3-Diphenyl-cyclopropancarbonsaeure(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-trans-2.3-Diphenyl-cyclopropancarbonsaeure(3471-08-7)
• EPA Substance Registry System: (-)-trans-2.3-Diphenyl-cyclopropancarbonsaeure(3471-08-7)

Safety Data

• Hazardous Substances Data: 3471-08-7(Hazardous Substances Data)

Upstream product

• 7381-89-7 2r,3c-diphenyl-cyclopropane-carboxylic acid-(1ξ)-ethyl ester 
• 623-73-4 diazoacetic acid ethyl ester 
• 103-30-0 (E)-1,2-diphenyl-ethene 
• 939-87-7 (1SR,2SR)-2-phenylcyclopropanecarbonyl chloride 
• 33044-88-1 (3,3-dibromocyclopropane-1,2-diyl)dibenzene 
• 7381-89-7 ethyl ester of (racemic) 2,3-diphenylcyclopropane-1-carboxylic acid 
• 75228-38-5 cis-2,3-diphenyl-1,1-cyclopropanedicarboxylic acid 
• 75228-38-5 trans-2,3-diphenyl-1,1-cyclopropanedicarboxylic acid 
• 124-38-9 carbon dioxide 
• 61608-79-5 ((1R*,2R*)-3-bromocyclopropane-1,2-diyl)dibenzene 
• 645-49-8 cis-stilben 

Downstream Products

• 20431-64-5 ethyl N-((E)-2,3-diphenylcyclopropyl)carbamate 
• 34293-21-5 rac-(1E, 5E)-1,3,4,6-tetraphenyl-1,5-hexadiene 
• 71117-29-8 meso-(1E, 5E)-1,3,4,6-tetraphenyl-1,5-hexadiene 
• 20431-65-6 C₁₈H₁₈N₂O₃ 
• 20431-65-6 ethyl N-nitroso-N-((E)-2,3-diphenylcyclopropyl)carbamate 
• 19817-60-8 1-Methoxy-trans-2,3-diphenyl-cyclopropan 

Relevant articles and documents

Erratum: Auxiliary-Enabled Pd-Catalyzed Direct Arylation of Methylene C(sp3)-H Bond of Cyclopropanes: Highly Diastereoselective Assembling of Di- and Trisubstituted Cyclopropanecarboxamides (Org. Lett. (2013) 15: 13 (3238-3241) DOI:10.1021/ol4012212)

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Trans N-Methyl-N-[2-(1-pyrrolidinyl)cyclohexyl] cycloprop-2-ene-1-carboxamides: Novel lipophilic kappa opioid agonists

The synthesis and kappa opioid agonist activities of some lipophilic analogues of the kappa opioid agonist U-50488 incorporating motifs bearing two aromatic rings in place of the 3,4-dichlorophenyl group are described. Trans 2,3-diphenyl-N-methyl-N[2-(1-pyrrolidinyl)cyclohexyl]-2-cyclopropene-1 -carboxamide, 7, is a potent kappa opioid agonist. A diphenylcyclopropene analogue of CI-977, trans 2,3-diphenyl-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]-2 -cyclopropene-1-carboxamide, 13, is a highly lipophilic chemically novel potent selective kappa opioid agonist.

New Host Family Based on Small-Ring Compounds

Three- and four-membered ring compounds with functional groups and bulky substituents have proved to be a rewarding new source of inclusion hosts.These hosts form clathrates with a variety of uncharged organic molecules ranging from protic dipolar to apolar compounds (168 different inclusion species).Formation and selectivity depend in a systematic manner on structural parameters of the host, such as the nature, number, and position of functional groups, the substituents, and ring size.X-ray structure analyses of two inclusion compounds 12121; = 9.782 (1), b = 11.376 (1), c = 17.603 (1) Angstroem; Z = 4. 17*MeCN (1:1): Pbcn; a = 12.314 (1), b = 16.074 (1), c = 12.938 (1) Angstroem; Z = 4> and of a free host molecule 1; a = 7.339 (2), b = 11.657 (4), c = 9.149 (3) Angstroem; β = 110.070; Z = 2> are reported, revealing the building principles of the new clathrate family.The structures exhibit linear chains of inter-/intramolecular H bridges between carboxylic groups in the free host 1 and H-bridge aggregation of host and guest molecules in infinite helical chains for the 1*t-BuOH (1:1) inclusion.In 17*MeCN (1:1), the guest molecules are tightly enclosed by the host framework without further specific interactions.