347389-88-2Relevant academic research and scientific papers
Direct synthesis of 2-aryl-4-quinolones via transition-metal-free intramolecular oxidative C(sp3)-H/C(sp3)-H coupling
Hu, Wei,Lin, Jian-Ping,Song, Li-Rui,Long, Ya-Qiu
supporting information, p. 1268 - 1271 (2015/05/20)
A novel, metal-free oxidative intramolecular Mannich reaction was developed between secondary amines and unmodified ketones, affording a simple and direct access to a broad range of 2-arylquinolin-4(1H)-ones through C(sp3)-H activation/C(sp3)-C(sp3) bond formation from readily available N-arylmethyl-2-aminophenylketones, using TEMPO as the oxidant and KOtBu as the base.
Iridium catalysed chemoselective alkylation of 2′-aminoacetophenone with primary benzyl type alcohols under microwave conditions
Bhat, Shailen,Sridharan, Visuvanathar
supporting information; experimental part, p. 4701 - 4703 (2012/05/31)
2′-Aminoacetophenone was chemoselectively alkylated with a range of substituted benzyl, heteroaryl alcohols to afford either the corresponding C- or N- alkylated products in good yield.
On the synthesis and reactivity of 1-benzyl-2-arylquinoline-4-thiones
Niedzinski, Edmund J.,Lashley, Matthew R.,Nantz, Michael H.
, p. 623 - 627 (2007/10/03)
A panel of 1-benzyl-2-aryl-4-quinolones was synthesized in three steps and converted to the corresponding 4-thione derivatives using Lawesson's reagent. The representative vinylogous thioamide (5a) was alkylated to afford a novel series of quinolinium sal
