34741-24-7Relevant academic research and scientific papers
Quinazolinone Compound and Application Thereof
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, (2020/11/27)
The present invention relates to a series of quinazolinone compounds and applications thereof as PI3Kα inhibitors. In particular, the present invention relates to a compound shown in formula (I) and a tautomer or pharmaceutically acceptable salt thereof.
3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF
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, (2017/10/06)
The present invention provides compounds, compositions thereof, and methods of using the same.
CYCLOALKYL-SUBSTITUTED IMIDAZOLE DERIVATIVE
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Paragraph 0280-0282, (2013/03/26)
A compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof, wherein A represents a C3 to C12 cycloalkyl group which may be substituted by one to three selected from a fluoro group, a hydroxy group, a C1 to C6 alkyl group, etc; R1, R2, and R3 each independently represent a hydrogen atom, a fluoro group, or a C1 to C6 alkyl group; R4 represents a hydrogen atom or a prodrug group; and Y represents -CH2-CHR5-CH2-NHR6 (wherein R5 represents a hydrogen atom, a C1 to C6 alkyl group, or a C1 to C6 alkoxy group, and R6 represents a hydrogen atom or a prodrug group), or the like exhibits excellent TAFIa inhibitory activity and is useful as a therapeutic drug for myocardial infarction, angina pectoris, acute coronary syndrome, cerebral infarction, deep vein thrombosis, pulmonary embolism, and the like.
Lipase-catalysed N-acylation of β2-amino esters
Fitz, Monika,Forro, Eniko,Vigoczki, Edina,Lazar, Laszlo,Fueloep, Ferenc
, p. 1114 - 1119 (2008/09/20)
The Candida antarctica lipase A-catalysed N-acylation of ethyl 3-amino-2-ethylpropanoate rac-3 and methyl 3-amino-2-isopropylpropanoate rac-6 was performed with ethyl butanoate in tert-amyl alcohol at 4 °C. The resulting enantiomerically enriched derivati
