ethyl 2-(aMinoMethyl)butanoate

Base Information

• Chemical Name: ethyl 2-(aMinoMethyl)butanoate
• CAS No.: 34741-24-7
• Molecular Formula: C7H15NO2
• Molecular Weight: 145.2
• Hs Code.: 2922499990
• Mol file: 34741-24-7.mol

Synonyms:2-Aminomethyl-buttersaeure-aethylester;ethyl 3-amino-2-ethylpropanoate;2-aminomethyl-butyric acid ethyl ester;

Chemical Property of ethyl 2-(aMinoMethyl)butanoate

Chemical Property:

• Boiling Point: 95-96℃ (31 Torr)
• PKA: 8.85±0.10(Predicted)
• Flash Point: 69.6±20.1℃
• PSA: 52.32000
• Density: 0.957±0.06 g/cm3 (20 oC 760 Torr)
• LogP: 1.23470
• Storage Temp.: 2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

Ethyl2-(aminomethyl)butanoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 2-(aMinoMethyl)butanoate

There total 5 articles about ethyl 2-(aMinoMethyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

ethyl 3-benzylamino-2-ethylpropanoate (63987-70-2) → (±)-ethyl 2-(aminomethyl)butanoate (34741-24-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 25 ℃; for 20h; under 760.051 Torr;

DOI:10.1016/j.tetasy.2008.04.002

Reference yield:

2-cyano-butyric acid ethyl ester (1619-58-5) → (±)-ethyl 2-(aminomethyl)butanoate (34741-24-7)

Guidance literature:

With hydrogen; nickel; In ethanol;

Reference yield:

ethyl 2-cyanoacetate (105-56-6) → (±)-ethyl 2-(aminomethyl)butanoate (34741-24-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 16 h / 20 °C

2: hydrogen / ethanol; water / 16 h / 25 °C / 2585.81 Torr

With hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethanol; water; N,N-dimethyl-formamide;

upstream raw materials:

ethyl 3-benzylamino-2-ethylpropanoate

2-cyano-butyric acid ethyl ester

triethyl 2-ethylphosphonoacetate

ethyl 2-methylenebutyrate

Downstream raw materials:

ethyl 4-{[(tert-butoxycarbonyl)amino]methyl}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hex-2-enoate

ethyl 4-{[(tert-butoxycarbonyl)amino]methyl}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hexanoate

4-(aminomethyl)-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hexanoic acid hydrochloride

Refernces

• 1、 -. "3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF". Paragraph 00424. . Retrieved 2017/10/06.
• 2、 Fitz, Monika,Forro, Eniko,Vigoczki, Edina,Lazar, Laszlo,Fueloep, Ferenc. "Lipase-catalysed N-acylation of β2-amino esters". . p. 1114 - 1119. Retrieved 2008/09/20.