34743-89-0

Basic information

• Product Name: Ethanol, 2-(2-broMophenoxy)-
• Synonyms: Ethanol, 2-(2-broMophenoxy)-
• CAS NO: 34743-89-0
• Molecular Formula: C₈H₉BrO₂
• Molecular Weight: 217.05986
• Mol File: 34743-89-0.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanol, 2-(2-broMophenoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanol, 2-(2-broMophenoxy)-(34743-89-0)
• EPA Substance Registry System: Ethanol, 2-(2-broMophenoxy)-(34743-89-0)

Safety Data

• Hazardous Substances Data: 34743-89-0(Hazardous Substances Data)

Usage

General Description

Ethanol, 2-(2-bromophenoxy)-, also known as 2-Bromo-2-phenoxyethanol, is a chemical compound with the molecular formula C8H9BrO2. It is an organic compound with a bromo and phenoxy functional group, and is commonly used as a preservative in various personal care and cosmetic products, as well as in pharmaceuticals and industrial applications. It is known for its antimicrobial properties and is often used as a broad-spectrum preservative to prevent the growth of bacteria, fungi, and yeast in products such as shampoos, conditioners, lotions, and creams. However, it has been the subject of regulatory scrutiny due to concerns about its potential health and environmental impacts.

Upstream product

• 95-56-7 2-hydroxybromobenzene 
• 540-51-2 2-bromoethanol 
• 96-49-1 [1,3]-dioxolan-2-one 
• 445283-15-8 2-bromophenoxyethyl tetrahydro-2H-pyran-2-yl ether 
• 107-07-3 2-chloro-ethanol 
• 122-99-6 2-Phenoxyethanol 

Downstream Products

• 1611492-82-0 C₁₁H₁₃BrO₃ 
• 1579960-88-5 1-(2-(2-bromophenoxy)ethoxy)-3-(4-(2-(tert-butyl)phenyl)piperazin-1-yl)propan-2-ol 
• 1379658-96-4 1-(2-bromophenoxy)-4-(2-phenoxyphenyl)but-3-yn-2-one 
• 1379658-68-0 rac-1-(2-bromophenoxy)-4-(2-(3-(trifluoromethyl)phenoxy)phenyl)but-3-yn-2-ol 
• 1379658-67-9 rac-1-(2-bromophenoxy)-4-(2-(3-fluorophenoxy)phenyl)but-3-yn-2-ol 
• 1379658-45-3 rac-1-(2-bromophenoxy)-4-(2-phenoxyphenyl)but-3-yn-2-ol 
• 1235552-90-5 acetic acid 2-(2-bromophenoxy)ethyl ester 
• 1120371-05-2 (E)-1-(2-bromophenyl)-3-methylpent-3-en-2-ol 
• 255847-81-5 1-[(4-cyano-5-methyl-4-phenyl)hexyl]-4-[2-(2-bromophenoxy)ethyl]piperazine 
• 94897-02-6 2-(2-o-bromophenoxyethyl)thiouronium p-toluenesulfonate 
• 94896-76-1 (R,R)-bis-<2-ethyl> phenylphosphonate 
• 94896-84-1 (R,R)-1,5-bis-3-thiapentane S-oxide 
• 94896-83-0 (R,R)-1,5-bis-3-thiapentane 
• 94896-82-9 1,5-bis(o-bromophenoxy)-3-thiapentane 

Relevant articles and documents

Light-Promoted Nickel Catalysis: Etherification of Aryl Electrophiles with Alcohols Catalyzed by a NiII-Aryl Complex

A highly effective C?O coupling reaction of (hetero)aryl electrophiles with primary and secondary alcohols is reported. Catalyzed by a NiII-aryl complex under long-wave UV (390–395 nm) irradiation in the presence of a soluble amine base without any additional photosensitizer, the reaction enables the etherification of aryl bromides and aryl chlorides as well as sulfonates with a wide range of primary and secondary aliphatic alcohols, affording synthetically important ethers. Intramolecular C?O coupling is also possible. The reaction appears to proceed via a NiI–NiIII catalytic cycle.

Sequential alcohol oxidation/putative homo Claisen-Tishchenko-type reaction to give esters: A key process in accessing novel biologically active lactone macrocycles

We report an efficient methodology for the direct oxidative esterification of primary alcohols to diether-esters using pyridinium chlorochromate (PCC). Numerous studies were carried out to probe the reaction mechanism and at the same time optimize the reaction conditions. The reaction could be conducted with 1 equivalent of PCC and 1 equivalent of BF3·OEt2. Indications based on literature precedent were that the reaction may proceed via a sequential alcohol oxidation to the aldehyde followed by a putative Cr or boron catalyzed Claisen-Tishchenko-type reaction. Using this efficient methodology, we synthesized a family of novel diether-esters in very good yields; some of these molecules were subsequently tested against both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). In addition, we also disclose a new synthetic strategy for the synthesis of lactam macrocycles with potential biological activity. This methodology included the regioselective borylation of the ester substrate and a subsequent Suzuki-Miyaura coupling to obtain the desired lactam macrocycle.

Synthesis of tetrasubstituted alkenes through a palladium-catalyzed domino carbopalladation/C-H-activation reaction

Helical tetrasubstituted alkenes (7) were obtained in a highly efficient way through a palladium-catalyzed domino-carbopalladation/CH-activation reaction of propargylic alcohols 6 in good to excellent yields. Electron-withdrawing- and electron-donating substituents can be introduced onto the upper and lower aromatic rings. The substrates (6) for the domino process were synthesized by addition of the lithiated alkyne (20) to various aldehydes (19); moreover, the substrates were accessible enantioselectively (in 95 % ee) by reduction of the corresponding ketone using the Noyori procedure. Copyright