34773-49-4Relevant academic research and scientific papers
Direct trifluoroacetylation of mono- and disubstituted thiophene derivatives
Andicsová-Eckstein, Anita,Kozma, Erika,Puterová-Tokárová, Zita,Végh, Daniel
, p. 272 - 275 (2015/11/24)
A convenient "one-pot" Friedel-Crafts reaction of mono-, bi- and tert-thiophenes with trifluoroacetic acid anhydride (TFAA) as an acylating agent and magnesium perchlorate dihydrate (anhydron) as catalyst affords trifluoroacetyl-substituted products in hi
Identification of novel, selective, and stable inhibitors of class II histone deacetylases. Validation studies of the inhibition of the enzymatic activity of HDAC4 by small molecules as a novel approach for cancer therapy
Ontoria, Jesus M.,Altamura, Sergio,Di Marco, Annalise,Ferrigno, Federica,Laufer, Ralph,Muraglia, Ester,Palumbi, Maria Cecilia,Rowley, Michael,Scarpelli, Rita,Schultz-Fademrecht, Carsten,Serafini, Sergio,Steinkühler, Christian,Jones, Philip
experimental part, p. 6782 - 6789 (2010/07/02)
5-Aryl-2-(trifluoroacetyl)thiophenes were identified as a new series of class II HDAC inhibitors (HDACi). Further development of this new series led to compounds such as 6h, a potent inhibitor of HDAC4 and HDAC6 (HDAC4 WT IC 50 = 310 nM, HDAC6
NANOENGINEERED ORGANIC NONLINEAR OPTICAL GLASSES
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Page/Page column 10, (2009/05/28)
Nonlinear optically active compounds having film-forming properties, films including the compounds, methods for making the compounds and films, and electro-optic devices including the films and compounds.
Electron acceptors for nonlinear optical chromophores
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Page/Page column 21, (2008/12/08)
Electron acceptor compounds, nonlinear optical chromophores made from the electron acceptor compounds, methods for making the electron acceptor compounds and nonlinear optical chromophores, lattices that include the nonlinear optical chromophores, and devices that include the nonlinear optical chromophores.
THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS
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Page/Page column 61, (2008/06/13)
The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts and tautomers thereof. Compounds of the present invention are inhibitors of histone deacetylase (HDAC) and are useful for treating cellular proliferative dise
