34773-51-8

Usage

Uses

Used in Pharmaceutical Research:
1-(5-bromothiophen-2-yl)-2,2,2-trifluoroethanone is used as a key intermediate in the synthesis of pharmaceutical compounds for various therapeutic applications. Its unique structure and reactivity allow for the development of novel drug candidates with specific characteristics, contributing to the advancement of medicinal chemistry.
Used in Agrochemicals:
In the agrochemical industry, 1-(5-bromothiophen-2-yl)-2,2,2-trifluoroethanone is utilized as a building block for the synthesis of agrochemicals, such as pesticides and herbicides. Its functional groups and reactivity enable the creation of compounds with targeted biological activities, enhancing crop protection and yield.
Used in Materials Science:
1-(5-bromothiophen-2-yl)-2,2,2-trifluoroethanone is employed as a precursor in the development of new materials with specific properties for various applications in materials science. Its unique structure and reactivity contribute to the synthesis of materials with tailored characteristics, such as improved thermal stability, electrical conductivity, or mechanical strength.
Used in Organic Synthesis:
As a versatile building block, 1-(5-bromothiophen-2-yl)-2,2,2-trifluoroethanone is used in organic synthesis for the preparation of a wide range of organic compounds. Its functional groups and reactivity facilitate the synthesis of diverse compounds with specific properties, making it a valuable tool in the development of new organic molecules for various applications.

Upstream product

• 35304-69-9 1-(5-bromothiophen-2-yl)-2,2,2-trifluoroethanol 
• 3141-27-3 2,5-dibromothiophen 
• 104863-67-4 N-methoxy-N-methyltrifluoroacetamide 
• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 
• 1236066-84-4 5-bromo-N-methoxy-N-methylthiophene-2-carboxamide 
• 31555-60-9 5-bromothiophene-2-carbonyl chloride 

Downstream Products

• 34773-49-4 2,2,2-trifluoro-1-(5-phenylthiophen-2-yl)ethanone 
• 35304-69-9 1-(5-bromothiophen-2-yl)-2,2,2-trifluoroethanol 

Relevant academic research and scientific papers

Electron-Accepting π-Conjugated Molecules with Fluorine-Containing Dicyanovinylidene as Terminal Groups: Synthesis, Properties, and Semiconducting Characteristics

A series of electron-accepting π-conjugated molecules having fluorine-containing dicyanovinylidene as terminal groups has been synthesized for the application to electron-transporting semiconductors. This terminal group can be easily incorporated into π-conjugated frameworks. Electrochemical measurements indicated that these compounds showed low-lying lowest unoccupied molecular orbital energy levels, which could be fine-tuned by the combination of central unit. The thin films fabricated by solution process showed typical electron-transporting characteristics in field-effect transistors.

Oxidation of α-trifluoromethyl and non-fluorinated alcohols: Via the merger of oxoammonium cations and photoredox catalysis

We present an alcohol oxidation strategy to access α-trifluoromethyl ketones (TFMKs) merging catalytic oxoammonium cation oxidation with visible-light photoredox catalysis. This work uses 4-acetamido-(2,2,6,6-tetramethyl-piperidin-1-yl)oxyl as an organic oxidant capable of generating TFMKs in good yields. The methodology serves as an improvement over previous reports of an analogous oxidation strategy requiring superstoichiometric quantities of oxidant. Both primary and secondary non-fluorinated alcohols can also be oxidised in good yields.

COMPOUNDS AND METHODS for the inhibition of HDAC

Disclosed are compounds having the formula: wherein X1, X2, X3, R1, R2, R3, R4, Y, A, Z, L and n are as defined herein, and methods of making and using the same.

A Weinreb amide approach to the synthesis of trifluoromethylketones

A novel route to access trifluoromethylketones (TFMKs) from Weinreb amides is reported. This represents the first documented case of the Ruppert-Prakash reagent (TMS-CF3) reacting in a constructive manner with an amide and enables synthesis of TMFKs without risk of over-trifluoromethylation.

Identification of novel, selective, and stable inhibitors of class II histone deacetylases. Validation studies of the inhibition of the enzymatic activity of HDAC4 by small molecules as a novel approach for cancer therapy

5-Aryl-2-(trifluoroacetyl)thiophenes were identified as a new series of class II HDAC inhibitors (HDACi). Further development of this new series led to compounds such as 6h, a potent inhibitor of HDAC4 and HDAC6 (HDAC4 WT IC 50 = 310 nM, HDAC6

THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS

The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts and tautomers thereof. Compounds of the present invention are inhibitors of histone deacetylase (HDAC) and are useful for treating cellular proliferative dise

Process for preparing trifluoromethyl ketones

A process is described for preparing trifluoromethyl ketones of the formula I STR1 where R has the given meanings, wherein an alcohol of the formula II STR2 is reacted with a compound of the formula IV where n has the given meaning.