34782-60-0Relevant articles and documents
Synthesis of thiadiazoles and 1,2,4-triazoles derived from cyclopropane dicarboxylic acid
Sharba, A. Hussain K.,Al-Bayati, Rida H.,Rezki, Nadjet,Aouad, Mohammed R.
, p. 1153 - 1160 (2005)
New heterocyclic derivatives of cyclopropane dicarboxylic acid comprising thiadiazole and 1,2,4-triazole moieties are reported. Reaction of 1,1-cyclopropane dicarboxylic acid (1) with thiosemicarbazide and phosphorous oxychloride resulted in 1,1-bis (2-am
Catalytic Asymmetric Homologation of 4-Substituted Cyclohexanones with CF3CHN2: Enantioselective Synthesis of α-Trifluoromethyl Cycloheptanones
Li, Shu-Sen,Sun, Shuo,Wang, Jianbo
supporting information, (2021/12/27)
Introduction of the trifluoromethyl group (CF3) into organic molecules in an enantioselective manner has attracted significant attention, but still remains a challenging problem. We herein report a catalytic asymmetric trifluoromethylation of cyclic ketones via a ScIII/chiral bisoxazoline-catalyzed homologation reaction by employing 2,2,2-trifluorodiazoethane (CF3CHN2) as the CF3 source. This desymmetrization process is highly efficient and generates two chiral centers with excellent diastereoselectivity and enantioselectivity, affording chiral α-trifluoromethyl cyclic ketones in a straightforward manner.
Catalytic Desymmetric Cycloaddition of Diaziridines with Metalloenolcarbenes: The Role of Donor–Acceptor Cyclopropenes
Zheng, Haifeng,Doyle, Michael P.
supporting information, p. 12502 - 12506 (2019/08/16)
A chiral copper(I) complex catalyzes reactions of symmetric diaziridines with enol diazo compounds, which react through N?N bond ring opening in a formal [3+3] cycloaddition to form four chiral centers with high stereocontrol. A broad spectrum of bridged dinitrogen heterocycles were obtained in high yields and excellent diastereo- and enantioselectivities from γ-substituted enol diazoacetates, while their geometrical isomers gave different enantioselectivities. Donor–acceptor cyclopropenes formed from the geometrical isomers of the γ-substituted enol diazoacetates underwent catalytic ring opening to give only the Z isomer of the metalloenolcarbene intermediate, provided excellent yields and selectivities for the 1,5-diazabicyclo[n.3.1]non-2-ene derivatives.
A deuterium generation of card abundantly for nepal derivatives, preparation method thereof, and wherein the intermediate application
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Paragraph 0146; 0147, (2018/03/26)
The invention belongs to the technical field of pharmaceutical chemistry, and discloses a deuterated cabozantinib derivative, a preparation method and an application thereof, and an intermediate of the deuterated cabozantinib derivative. The deuterated ca
