3479-10-5

Basic information

• Product Name: 2-Amino-4chlorobenzenesulfonic acid
• Synonyms: 2-Amino-4chlorobenzenesulfonic acid;4-Chloro-2-aminobenzenesulfonic acid;2-azanyl-4-chloro-benzenesulfonic acid;4-Chloro-2-sulphoaniline
• CAS NO: 3479-10-5
• Molecular Formula: C₆H₆ClNO₃S
• Molecular Weight: 207.63474
• Mol File: 3479-10-5.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Density: 1.642g/cm³
• Refractive Index: 1.639
• CAS DataBase Reference: 2-Amino-4chlorobenzenesulfonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-4chlorobenzenesulfonic acid(3479-10-5)
• EPA Substance Registry System: 2-Amino-4chlorobenzenesulfonic acid(3479-10-5)

Safety Data

• Hazardous Substances Data: 3479-10-5(Hazardous Substances Data)

Usage

Organic compound

2-Amino-4-chlorobenzenesulfonic acid

Chemical structure

Benzene ring with a chlorine atom and a sulfonic acid group

Uses

Manufacturing of dyes, pigments, chemicals, pharmaceuticals, agrochemicals

Physical appearance

White to off-white crystalline powder

Solubility

Soluble in water

Toxicity

Moderately toxic

Health effects

Irritation to skin, eyes, respiratory system upon contact

InChI:InChI=1/C6H6ClNO3S/c7-4-1-2-6(5(8)3-4)12(9,10)11/h1-3H,8H2,(H,9,10,11)

Upstream product

• 4153-06-4 4-chloro-2-nitrobenzenesulfenyl chloride 
• 108-42-9 3-chloro-aniline 
• 2786-51-8 5-chlorobenzo[d]thiazole 
• 110-01-0 thiophene 
• 7664-93-9 sulfuric acid 
• 2050-66-0 bis(2-nitro-4-chlorophenyl)disulfide 

Downstream Products

• 89284-57-1 3-chloro-2,4,6-tribromoaniline 
• 108130-16-1 4-chloro-2-[(ethoxycarbonyl)amino]benzenesulfonyl chloride 
• 1083418-39-6 4-chloro-2-{[5-(4-chloro-phenyl)-2-trifluoromethyl-furan-3-carbonyl]-amino}-benzene-sulfonic acid 
• 1034331-54-8 2-((E)-3-biphenyl-4-yl-acryloylamino)-4-chloro-benzenesulfonic acid 
• 1034331-52-6 4-chloro-2-((E)-3-naphthalen-2-yl-acryloylamino)-benzenesulfonic acid 
• 105548-25-2 2-(2-Acetylamino-4-diethylamino-phenylazo)-4-chloro-benzenesulfonic acid 
• 105547-87-3 2-(4-Amino-2-diethylamino-6-methyl-pyrimidin-5-ylazo)-4-chloro-benzenesulfonic acid 
• 105547-66-8 2-(5-Amino-3-methyl-1-phenyl-1H-pyrazol-4-ylazo)-4-chloro-benzenesulfonic acid 
• 105548-06-9 4-Chloro-2-(4,6-diamino-2-ethylsulfanyl-pyrimidin-5-ylazo)-benzenesulfonic acid 

Relevant articles and documents

1,2,4-Benzothiadiazine-1,1-dioxide derivatives as Ionotropic glutamate receptor ligands: Synthesis and structure-activity relationships

Ionotropic glutamate receptor (iGluR) modulators, specially AMPA receptor antagonists, are potential tools for numerous therapeutic applications in neurological disorders, including Alzheimer's and Parkinson's diseases, amyotrophic lateral sclerosis, epil

Development of an efficient ruthenium catalyzed synthetic process and mechanism for the facile conversion of benzothiazoles to orthanilic acids

Ruthenium-Schiff base complex catalyzed efficient protocol has been developed for the synthesis of orthanilic acids from benzothiazoles in good to excellent yields using N-haloamines. Hexa-coordinated ruthenium complex with Schiff base and triphenylphosphine ligands has been prepared and its catalytic function was invented for the synthesis of orthanilic acids. The synthetic process utilizes our efficient method for the selective and preferential oxidation of thiazole ring of benzothiazoles using N-haloamines without effecting phenyl ring. The detailed catalytic, mechanistic and kinetic investigations have been made for the synthetic reactions. Solvent isotope studies have been made in H2O-D2O and the reactions were carried out at different temperatures. Under the identical set of conditions, the kinetics of catalyzed reactions has been compared with uncatalyzed reactions and found that the catalyzed reactions are 9-11 folds faster. The catalytic constants (KC) have been calculated for each N-haloamine at different temperatures and the values of activation parameters with respect to the catalyst have been evaluated. Spectroscopic evidence for the formation of 1:1 complex between N-haloamine and ruthenium has been obtained. The observed results have been explained by a plausible mechanism and the related rate law has been deduced.

NOVEL ARYL UREIDO BENZOIC ACID DERIVATIVES AND THEIR USE

This invention relates to novel aryl ureido benzoic acid derivatives useful as selective and non-competitive antagonists of the ionotropic GluR5 receptor. Due to their biological activity, the aryl ureido derivatives of the invention are considered useful for treating diseases that are responsive to modulation of an aspartate or a glutamate receptor. Moreover the invention provides chemical compounds for use according to the invention, as well as pharmaceutical compositions comprising the chemical compounds, and methods of treating diseases or disorders or conditions responsive to modulation of an aspartate or a glutamate receptor.