347975-19-3

Upstream product

• 347974-70-3 1-[1-(4-benzyloxyphenyl)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-2,2,2-trifluoroethanone 
• 347974-65-6 1-(4-benzyloxyphenyl)-6-methoxy-3,4-dihydroisoquinoline 
• 347974-48-5 4-benzyloxy-N-[2-(3-methoxyphenyl)ethyl]benzamide 
• 1486-51-7 p-(benzyloxy)benzoic acid 
• 2039-67-0 2-(3-methoxyphenyl)-1-ethanamine 
• 347974-60-1 1-(4-benzyloxyphenyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline 

Downstream Products

• 347977-92-8 2,2,2-trifluoro-1-{6-methoxy-1-[4-(2-pyrrolidin-1-yl-ethoxy)phenyl]-3,4-dihydro-1H-isoquinolin-2-yl}ethanone 
• 347976-16-3 6-benzyloxy-2-(naphthalene-1-sulfonyl)-1-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-1,2,3,4-tetrahydroisoquinoline 
• 347974-83-8 {6-benzyloxy-1-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-3,4-dihydro-1H-isoquinolin-2-yl}phenylmethanone 
• 347976-11-8 2-benzenesulfonyl-6-benzyloxy-1-[4-(2-pyrrolidin-1-yl-ethoxy)phenyl]-1,2,3,4-tetrahydroisoquinoline 
• 347974-74-7 1-{6-benzyloxy-1-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-3,4-dihydro-1H-isoquinolin-2-yl}-2,2,2-trifluoro-ethanone 
• 347976-38-9 6-Benzyloxy-1-[4-(2-pyrrolidin-1-yl-ethoxy)phenyl]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid ethyl ester 
• 347977-96-2 2,2,2-trifluoro-1-{6-hydroxy-1-[4-(2-pyrrolidin-1-yl-ethoxy)phenyl]-3,4-dihydro-1H-isoquinolin-2-yl}ethanone 
• 347974-78-1 6-benzyloxy-1-[4-(2-pyrrolidin-1-yl-ethoxy)phenyl]-1,2,3,4-tetrahydroisoquinoline 
• 347976-28-7 1-[4-(2-pyrrolidin-1-yl-ethoxy)phenyl]-1,2,3,4-tetrahydroisoquinolin-6-ol 

Relevant academic research and scientific papers

Tetrahydroisoquinolines as subtype selective estrogen agonists/antagonists

Two series of 6-hydroxy and 7-hydroxy tetrahydroisoquinolines were prepared. Evaluating a range of C-1, C-4, and N-substituents led to the discovery of ER α and ER β selective analogs.

Tetrahydroisoquinoline compounds as estrogen agonists/antagonists

This invention relates to compounds useful for treating or preventing obesity, breast cancer, osteoporosis, endometriosis, cardiovascular disease, prostatic disease, and the like, and to pharmaceutical composition, methods, and kits comprising such compou