348-91-4

Basic information

• Product Name: N-[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl chloride
• Synonyms: N-[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl chloride
• CAS NO: 348-91-4
• Molecular Weight: 258.027
• Mol File: 348-91-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl chloride(348-91-4)
• EPA Substance Registry System: N-[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl chloride(348-91-4)

Safety Data

• Hazardous Substances Data: 348-91-4(Hazardous Substances Data)

Upstream product

• 7693-46-1 4-Nitrophenyl chloroformate 
• 320-51-4 4-chloro-3-trifluoromethyl-aniline 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 75-44-5 phosgene 

Downstream Products

• 1129683-83-5 4-[ ({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenol 
• 755037-03-7 regorafenib 
• 284461-73-0 sorafenib 

Relevant articles and documents

Preparation method of regorafenib

The invention relates to a preparation method of regorafenib. The method comprises the following steps: adding 4-chloro-3-trifluoromethylaniline and an alkaline reagent into an organic solvent of triphosgene, and stirring for reaction to obtain a compound 2; and then adding N-methyl-4-(4-amino-3-fluoro) phenoxy pyridine-2-formamide and an alkaline reagent into the organic solvent of the compound 2, and reacting to obtain the regorafenib. The method provided by the invention is short in reaction time, easy for large-scale preparation, easy to operate, good in stability, high in purity and yield, free of intermediate separation and suitable for industrial production.

Preparation method for medicine for treating tumors and application of medicine

The invention discloses a preparation method for a medicine for treating tumors and an application of the medicine. A structural formula of the medicine for treating the tumors is shown in the description. The preparation method disclosed by the invention greatly simplifies the operation steps, has a short reaction route, a stable reaction system, very good controllability, mild reaction conditions, low costs, and a higher total yield; the obtained product has higher purity; the medicine disclosed by the invention can inhibit growth of tumor cells, facilitate prolonging life span of patients,and improve quality of life of the patients; and the medicine has a very good therapeutic effect on human lung cancers, human melanoma and human fibrosarcoma.