34833-69-7Relevant academic research and scientific papers
Novel sulfonyloxymethylphosphonate derivatives and process for preparing diisopropyl ((1-(trityloxymethyl)-cyclopropyl)oxy)methylphosphonate using the same
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Paragraph 0064; 0117-0118, (2018/05/03)
PURPOSE: A method for preparing diisopropyl((1-(trityloxymethyl)-cyclopropyl)oxy)methyl phosphonate is provided to enable monitoring of reaction by HPLC having a UV detector. CONSTITUTION: A method for preparing diisopropyl((1-(trityloxymethyl)-cyclopropyl)oxy)methylphosphonate compound of chemical formula 2 comprises a step of reacting a sulfonyloxymethyl phosphonate compound of chemical formula 3 and 1-trityloxymethyl-cyclopropanol compound of chemical formula 10 in a solvent of 1-methyl-2-pyrrolidinone(NMP), N,N-dimethylaceteamide(DMAC), or N,N-dimethylformamide(DMF).
NUCLEOBASE PHOSPHONATE ANALOGS FOR ANTIVIRAL TREATMENT
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Page/Page column 98-99, (2008/06/13)
The present invention provides novel compounds with activity against infectious viruses. The compounds of the invention may inhibit retroviral reverse transcriptases and thus inhibit the replication of the virus. They are useful for treating human patients infected with a human retrovirus, such as human immunodeficiency virus (strains of HIV-1 or HIV-2) or human T-cell leukemia viruses (HTLV-I or HTLV-II) which results in acquired immunodeficiency syndrome (AIDS) and/or related diseases. The present invention also relates generally to the accumulation or retention of therapeutic compounds inside cells. The invention is more particularly related to attaining high concentrations of active metabolite molecules in HIV infected cells. Intracellular targeting may be achieved by methods and compositions which allow accumulation or retention of biologically active agents inside cells. Such effective targeting may be applicable to a variety of therapeutic formulations and procedures.
