34837-68-8

Basic information

• Product Name: 2-[methyl(phenylsulfonyl)amino]benzoic acid
• Synonyms: 2-[methyl(phenylsulfonyl)amino]benzoic acid;2-[benzenesulfonyl(methyl)amino]benzoic acid
• CAS NO: 34837-68-8
• Molecular Formula: C₁₄H₁₃NO₄S
• Molecular Weight: 291.33
• Mol File: 34837-68-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[methyl(phenylsulfonyl)amino]benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[methyl(phenylsulfonyl)amino]benzoic acid(34837-68-8)
• EPA Substance Registry System: 2-[methyl(phenylsulfonyl)amino]benzoic acid(34837-68-8)

Safety Data

• Hazardous Substances Data: 34837-68-8(Hazardous Substances Data)

Usage

Chemical compound

2-[methyl(phenylsulfonyl)amino]benzoic acid

Use

Intermediate in the synthesis of pharmaceuticals and agrochemicals

Structure

Benzene derivative with a methoxy group, a sulfonyl group, and an amino group attached to the benzene ring

Physical properties

White solid, molecular weight of 305.35 g/mol, melting point of 144-146 °C

Solubility

Soluble in organic solvents like methanol, ethanol, acetone; insoluble in water

Potential applications

Pharmaceutical and agrochemical industries due to structural properties and reactivity

Upstream product

• 119-68-6 N-Methylanthranilic acid 
• 98-09-9 benzenesulfonyl chloride 

Downstream Products

• 1859-76-3 2-(methylamino)benzophenone 

Relevant articles and documents

Deoxygenative Arylation of Carboxylic Acids by Aryl Migration

An unprecedented deoxygenative arylation of aromatic carboxylic acids has been achieved, allowing the construction of an enhanced library of unsymmetrical diaryl ketones. The synergistic photoredox catalysis and phosphoranyl radical chemistry allows for precise cleavage of a stronger C?O bond and formation of a weaker C?C bond by 1,5-aryl migration under mild reaction conditions. This new protocol is independent of substrate redox-potential, electronic, and substituent effects. It affords a general and promising access to 60 examples of synthetically versatile o-amino and o-hydroxy diaryl ketones under redox-neutral conditions. Furthermore, it also brings one concise route to the total synthesis of quinolone alkaloid, (±)-yaequinolone A2, and a viridicatin derivative in satisfying yields.