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Usage

Uses

Used in Pharmaceutical Research:
Chalcone is utilized as a key intermediate in the synthesis of flavonoids, which are essential in pharmaceutical research due to their diverse biological activities. These flavonoids have potential applications in the development of treatments for various diseases, including their antioxidant, anti-inflammatory, anti-cancer, and antimicrobial properties.
Used in Natural Product Chemistry:
In the field of natural product chemistry, chalcone serves as a valuable compound for the synthesis of flavonoids. These flavonoids are known for their wide range of biological activities, making them important targets for the development of new drugs and therapeutic agents.
Used in the Synthesis of Specific Flavonoids:
Chalcone is used as a precursor for the synthesis of specific flavonoids with potential therapeutic applications. These flavonoids can be further investigated and optimized for their efficacy in treating various diseases and conditions.
Used in Drug Delivery Systems:
Similar to gallotannin, chalcone and its derivatives can be incorporated into drug delivery systems to enhance their bioavailability, delivery, and therapeutic outcomes. This application can improve the overall effectiveness of chalcone-based treatments and expand their use in the pharmaceutical industry.

Upstream product

• 1065-88-9 p-Terephthaloyl-bis-methylen-triphenylphosphoran 
• 100-52-7 benzaldehyde 
• 1009-61-6 1,4-Diacetylbenzene 
• 103-49-1 dibenzylamine 
• 42472-69-5 4-ethynylacetophenone 
• 935-14-8 1,4-diethynylbenzene 
• 1205-91-0 benzene-1,4-diyl diacetate 

Downstream Products

• 143517-55-9 1,1'-terephthaloylbis<2-phenyl-3-(phenylsulfonyl)cyclopropane> 
• 95363-46-5 C₁₄₄H₁₀₈O₁₂ 
• 95462-20-7 21,22,23,24-tetraphenyl-1,4,11,14-tetraoxo-2(3),12(13)-diethano<4.4>paracyclophane 
• 95363-43-2 (E)-1-(4-{(1S,3R,4S)-2-[4-((1R,2R,3S,4S)-2,3-Diphenyl-4-{4-[(E)-(3-phenyl-acryloyl)]-benzoyl}-cyclobutanecarbonyl)-benzoyl]-3,4-diphenyl-cyclobutanecarbonyl}-phenyl)-3-phenyl-propenone 
• 95363-44-3 (E)-1-{4-[2-(4-{3-[4-(2,3-Diphenyl-4-{4-[(E)-(3-phenyl-acryloyl)]-benzoyl}-cyclobutanecarbonyl)-benzoyl]-2,4-diphenyl-cyclobutanecarbonyl}-benzoyl)-3,4-diphenyl-cyclobutanecarbonyl]-phenyl}-3-phenyl-propenone 
• 95363-45-4 C₁₂₀H₉₀O₁₀ 
• 90280-94-7 21,22,23,24-tetraphenyl-1,4,11,14-teraoxo-2(3),12(13)-diethano<4,4>paracyclophane 
• 143517-42-4 1,1'-terephthaloylbis<2-phenyl-3-(phenylthio)cyclopropane> 
• 132843-97-1 [4-(4-Phenyl-4,5-dihydro-1H-pyrazole-3-carbonyl)-phenyl]-(4-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-methanone 

Relevant academic research and scientific papers

Phosphorous Acid Promoted Hydration-Condensation of Aromatic Alkynes with Aldehydes Affording Chalcones in an Oil/Water Two-Phase System

A simple and environmentally benign method was developed for the synthesis of chalcones in high to excellent yields by a phosphorous acid promoted alkyne-aldehyde hydration-condensation in an oil/water two-phase system. The method is the first efficient protocol for the preparation of chalcones that is mediated by a simple Bronsted acid in a two-phase system.

Symmetric bis-chalcones as a new type of breast cancer resistance protein inhibitors with a mechanism different from that of chromones

Potent ABCG2 inhibitors were recently identified as asymmetric chromones with different types of substituents. We here synthesized symmetric bis-chalcones that were differently substituted and screened for their ability to inhibit mitoxantrone efflux from

Practical metal-free synthesis of chalcone derivatives via a tandem cross-dehydrogenative-coupling/elimination reaction

Metal-free synthesis of chalcone derivatives through a tandem cross-dehydrogenative-coupling/elimination reaction is described. A simple and inexpensive ammonium persulfate salt enables the reaction between ketones and benzylamines to proceed with high stereoselectivity and good functional group compatibility.

Synthesis, characterization and antimicrobial activities of some novel bis-chalcones

A series of novel bis-chalcones 3a-n were synthesized in excellent yields by condensation reaction of 1,4-diacetylbenzene with various aldehydes in ethanol 96% and aqueous NaOH at room temperature. All compounds were characterized by IR, 1H and

Convergence of absorption and fluorescence in cross-conjugated oligomers consisting of chalcone building blocks

The absorption and fluorescence spectra of two series of chalcone oligomers (1a-d) and (2a-d) are reported. Due to small or vanishing orbital coefficients (HMO calculation) within the cross-conjugated systems, the bathochromic shifts caused by the extensi

TOPOCHEMICAL "DOUBLE" PHOTOCYCLODIMERIZATION OF THE 1,4-DICINNAMOYLBENZENE CRYSTAL

The 1,4-dicinnaomoylbenzene crystal (1) dimerizes on photoirradiation into 21,22,23,24-tetraphenyl-1,4,11,14-tetraoxo-2(3),12(13)-diethanoparacyclophane (3) in an extremely hygh yield through the intermediate dimer 2 by "double" cyclodimerization wit

PHOTODIMERIZATION OF 1,4-DICINNAMOYLBENZENE CRYSTAL VIA A TOPOCHEMICAL PROCESS

1,4-Dicinnamoylbenzene crystals photodimerize readily via a double cycloaddition into the corresponding tricyclic dimer, which consist of two cyclobutane rings and a macro ring bridged by two phenylene linkages.