34838-64-7

Basic information

• Product Name: (E)-3-Phenyl-1-(4-[(E)-(3-phenyl-acryloyl)]-phenyl)-propenone
• Synonyms: (E)-3-Phenyl-1-(4-[(E)-(3-phenyl-acryloyl)]-phenyl)-propenone
• CAS NO: 34838-64-7
• Molecular Formula: C₂₄H₁₈O₂
• Molecular Weight: 338.39852
• Mol File: 34838-64-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 544.6°Cat760mmHg
• Flash Point: 199.8°C
• Appearance: /
• Density: 1.166g/cm³
• CAS DataBase Reference: (E)-3-Phenyl-1-(4-[(E)-(3-phenyl-acryloyl)]-phenyl)-propenone(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-Phenyl-1-(4-[(E)-(3-phenyl-acryloyl)]-phenyl)-propenone(34838-64-7)
• EPA Substance Registry System: (E)-3-Phenyl-1-(4-[(E)-(3-phenyl-acryloyl)]-phenyl)-propenone(34838-64-7)

Safety Data

• Hazardous Substances Data: 34838-64-7(Hazardous Substances Data)

Usage

General Description

(E)-3-Phenyl-1-(4-[(E)-(3-phenyl-acryloyl)]-phenyl)-propenone, also known as chalcone, is a chemical compound that belongs to the chalcone class of organic compounds. It is a yellow solid with a molecular formula C22H16O2 and a molecular weight of 312.36 g/mol. The compound has a characteristic α,β-unsaturated ketone structure, consisting of a central 1,3-diphenylprop-2-en-1-one unit with a substituted phenyl group at the 3-position and a conjugated phenylacryloyl group at the 1-position. Chalcone is commonly used as a precursor in the synthesis of various flavonoids, which are important in the field of natural product chemistry and pharmaceutical research due to their diverse biological activities, including antioxidant, anti-inflammatory, anti-cancer, and antimicrobial properties. Chalcone and its derivatives have also been investigated for their potential therapeutic applications in the treatment of various diseases.

Upstream product

• 42472-69-5 4-ethynylacetophenone 
• 100-52-7 benzaldehyde 
• 935-14-8 1,4-diethynylbenzene 
• 1065-88-9 p-Terephthaloyl-bis-methylen-triphenylphosphoran 
• 1205-91-0 benzene-1,4-diyl diacetate 
• 1009-61-6 1,4-Diacetylbenzene 
• 103-49-1 dibenzylamine 

Downstream Products

• 143517-42-4 1,1'-terephthaloylbis<2-phenyl-3-(phenylthio)cyclopropane> 
• 90280-94-7 21,22,23,24-tetraphenyl-1,4,11,14-teraoxo-2(3),12(13)-diethano<4,4>paracyclophane 
• 95363-45-4 C₁₂₀H₉₀O₁₀ 
• 95462-20-7 21,22,23,24-tetraphenyl-1,4,11,14-tetraoxo-2(3),12(13)-diethano<4.4>paracyclophane 
• 95363-43-2 (E)-1-(4-{(1S,3R,4S)-2-[4-((1R,2R,3S,4S)-2,3-Diphenyl-4-{4-[(E)-(3-phenyl-acryloyl)]-benzoyl}-cyclobutanecarbonyl)-benzoyl]-3,4-diphenyl-cyclobutanecarbonyl}-phenyl)-3-phenyl-propenone 
• 95363-44-3 (E)-1-{4-[2-(4-{3-[4-(2,3-Diphenyl-4-{4-[(E)-(3-phenyl-acryloyl)]-benzoyl}-cyclobutanecarbonyl)-benzoyl]-2,4-diphenyl-cyclobutanecarbonyl}-benzoyl)-3,4-diphenyl-cyclobutanecarbonyl]-phenyl}-3-phenyl-propenone 
• 95363-46-5 C₁₄₄H₁₀₈O₁₂ 
• 143517-55-9 1,1'-terephthaloylbis<2-phenyl-3-(phenylsulfonyl)cyclopropane> 
• 132843-97-1 [4-(4-Phenyl-4,5-dihydro-1H-pyrazole-3-carbonyl)-phenyl]-(4-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-methanone 

Relevant articles and documents

Phosphorous Acid Promoted Hydration-Condensation of Aromatic Alkynes with Aldehydes Affording Chalcones in an Oil/Water Two-Phase System

A simple and environmentally benign method was developed for the synthesis of chalcones in high to excellent yields by a phosphorous acid promoted alkyne-aldehyde hydration-condensation in an oil/water two-phase system. The method is the first efficient protocol for the preparation of chalcones that is mediated by a simple Bronsted acid in a two-phase system.

Practical metal-free synthesis of chalcone derivatives via a tandem cross-dehydrogenative-coupling/elimination reaction

Metal-free synthesis of chalcone derivatives through a tandem cross-dehydrogenative-coupling/elimination reaction is described. A simple and inexpensive ammonium persulfate salt enables the reaction between ketones and benzylamines to proceed with high stereoselectivity and good functional group compatibility.

Convergence of absorption and fluorescence in cross-conjugated oligomers consisting of chalcone building blocks

The absorption and fluorescence spectra of two series of chalcone oligomers (1a-d) and (2a-d) are reported. Due to small or vanishing orbital coefficients (HMO calculation) within the cross-conjugated systems, the bathochromic shifts caused by the extensi