3484-18-2

Basic information

• Product Name: 2-Ethyl-1H-indole
• Synonyms: 2-Ethyl-1H-indole;2-ETHYLINDOLE
• CAS NO: 3484-18-2
• Molecular Formula: C₁₀H₁₁N
• Molecular Weight: 145.2
• Mol File: 3484-18-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 46 °C
• Boiling Point: 281.9°Cat760mmHg
• Flash Point: 119.9°C
• Appearance: /
• Density: 1.078g/cm³
• Vapor Pressure: 0.00592mmHg at 25°C
• Refractive Index: 1.632
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 17.53±0.30(Predicted)
• CAS DataBase Reference: 2-Ethyl-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Ethyl-1H-indole(3484-18-2)
• EPA Substance Registry System: 2-Ethyl-1H-indole(3484-18-2)

Safety Data

• Hazardous Substances Data: 3484-18-2(Hazardous Substances Data)

Usage

General Description

2-Ethyl-1H-indole, also known as 2-ethylindole, is a chemical compound with the molecular formula C10H11N. It is a substituted indole derivative, belonging to the class of organic compounds known as indoles. 2-Ethyl-1H-indole is commonly used as a building block and intermediate in the synthesis of pharmaceuticals and agrochemicals. Its chemical structure consists of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring, with an ethyl group attached to the second carbon of the indole ring. 2-Ethyl-1H-indole has a variety of industrial applications and is also of interest in medicinal chemistry due to its potential pharmacological properties.

InChI:InChI=1/C10H11N/c1-2-9-7-8-5-3-4-6-10(8)11-9/h3-7,11H,2H2,1H3

Upstream product

• 1129-62-0 butan-2-one phenylhydrazone 
• 81784-64-7 3-Oxo-pentanoic acid hydroxy-phenyl-amide 
• 64074-05-1 2,2-dimethyl-5-propanoyl-1,3-dioxan-4,6-dione 
• 108-94-1 cyclohexanone 
• 100-63-0 phenylhydrazine 
• 95-20-5 2-methyl-1H-indole 
• 74-88-4 methyl iodide 
• 2696-85-7 2-butyl-benzenamine 
• 66696-76-2 5-(1-hydroxypropylidene)-2,2-dimethyl-[1,3]dioxane-4,6-dione 

Downstream Products

• 329015-26-1 2,5-dichloro-3-(2-ethyl-1H-indol-3-yl)[1,4]benzoquinone 
• 1555519-63-5 1-ethyl-2-[(4-methylphenyl)sulfonyl]-1H-indole 

Relevant articles and documents

Zirconium Metal-Organic Frameworks Assembled from Pd and Pt PNNNP Pincer Complexes: Synthesis, Postsynthetic Modification, and Lewis Acid Catalysis

Carboxylic acid-functionalized Pd and Pt PNNNP pincer complexes were used for the assembly of two porous Zr metal-organic frameworks (MOFs), 2-PdX and 2-PtX. Powder X-ray diffraction analysis shows that the new MOFs adopt cubic frame

New route to 2-substituted indoles by pyrolysis of N-acylacetylphenylhydroxylamines

Convenient and regiospecific synthesis of 2-substituted indol (3) by thermolysis of N-acylacetylphenylhydroxylamine (1) and its mechanism including the formation of a radical intermediate are reported.

Functionalization of the Methyl Group of 2-Methylindole by Direct Generation of a C,N-Dianion

The first method for directly generating C,N-dianion from an alkyl-substituted ?-excessive N-heterocyclic compound (2-methylindole) has been developed.It involves treatment with 3 equiv. of BuLi and 2 equiv. of ButOK in a particular sequence and results in the functionalization of the 2-methyl group of the indole in a regiospecific manner.