14470-51-0

Basic information

• Product Name: 5,6-DIHYDROTHIENO[2,3-C]PYRIDIN-7(4H)-ONE
• Synonyms: 5,6-DIHYDROTHIENO[2,3-C]PYRIDIN-7(4H)-ONE;5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one;5,6-Dihydrothieno[2,3-c]pyridin-7(4H);4H,5H,6H,7H-thieno[2,3-c]pyridin-7-one
• CAS NO: 14470-51-0
• Molecular Formula: C₇H₇NOS
• Molecular Weight: 153.20158
• Mol File: 14470-51-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 417.127°C at 760 mmHg
• Flash Point: 206.071°C
• Appearance: /
• Density: 1.295g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.597
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5,6-DIHYDROTHIENO[2,3-C]PYRIDIN-7(4H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-DIHYDROTHIENO[2,3-C]PYRIDIN-7(4H)-ONE(14470-51-0)
• EPA Substance Registry System: 5,6-DIHYDROTHIENO[2,3-C]PYRIDIN-7(4H)-ONE(14470-51-0)

Safety Data

• Hazardous Substances Data: 14470-51-0(Hazardous Substances Data)

Usage

Uses

5,6-dihydrothieno[2,3-c]pyridin-7(4H)-one is a useful research chemical.

InChI:InChI=1/C7H7NOS/c9-7-6-5(1-3-8-7)2-4-10-6/h2,4H,1,3H2,(H,8,9)

Upstream product

• 34843-84-0 2-(thiophen-3-yl)ethan-1-amine hydrochloride 
• 13781-53-8 (thiophen-3-yl)acetonitrile 
• 1195-52-4 3-(3-thienyl)-2-propenoic acid 
• 498-62-4 3-thiophene carboxaldehyde 
• 59311-67-0 2-(3-thienyl)ethylamine 
• 847140-00-5 C₇H₇NOS 
• 179061-06-4 N-tert-butoxycarbonyl-2-(3-thienyl)ethylamine 
• 16378-06-6 3-(3-thienyl)propanoic acid 
• 68559-67-1 6-acetyl-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one 
• 960289-02-5 (2-thiophen-3-yl-ethyl)-carbamic acid ethyl ester 
• 5650-52-2 4,5-dihydro-6H-cyclopenta[b]thiophen-6-one 
• 14600-24-9 4,5-dihydrocyclopenta[b]thiophen-6-one oxime 

Downstream Products

• 960289-03-6 2-bromo-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one 
• 960289-08-1 2-(4-methoxy-phenyl)-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one 
• 960402-67-9 (+/-)-2-(4-chloro-phenyl)-6-[3-methoxy-4-(pyrrolidine-3-carbonyl)-phenyl]-6H-thieno[2,3-c]pyridin-7-one trifluoroacetic acid 
• 960402-65-7 (+/-)-3-{4-[2-(4-chloro-phenyl)-7-oxo-7H-thieno[2,3-c]pyridin-6-yl]-phenylcarbamoyl}-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 960400-59-3 toluene-4-sulfonic acid 2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-phenyl ester 
• 960401-12-1 trifluoromethanesulfonic acid 2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-phenyl ester 
• 960402-73-7 (+/-)-pyrrolidine-3-carboxylic acid {4-[2-(4-chloro-phenyl)-7-oxo-7H-thieno[2,3-c]pyridin-6-yl]-phenyl}-amide 
• 960401-15-4 2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-benzoic acid 
• 960401-13-2 2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-benzoic acid methyl ester 
• 960400-65-1 6-(4-hydroxy-3-methoxy-phenyl)-2-(4-methoxy-phenyl)-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one 
• 960402-40-8 6-(4-bromo-phenyl)-2-(4-chloro-phenyl)-6H-thieno[2,3-c]pyridin-7-one 

Relevant articles and documents

FUSED THIOPHENE AND THIAZOLE DERIVATIVES AS ROR GAMMA MODULATORS

The present invention provides fused thiophene and thiazole derivatives of formula (I), which may be therapeutically useful, more particularly as RORγ modulators; in which R1, R2, R3, R4, R5, R6, R7, X1, X2, L, m, n and ring A have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention of diseases or disorders, in particular their use in disease(s) or disorder(s) where there is an advantage in modulating RORγ receptor. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the fused thiophene and thiazole derivatives of formula (I), together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

Synthesis of 3,4-dihydroisoquinolin-1-ones from N-Boc-(β-Arylethyl) carbamates via isocyanate intermediates

Mild reaction conditions for the regioselective synthesis of isoquinolin-1-ones and related fused-ring heterocycles from N-Boc-protected (β-arylethyl)carbamates are described. The reactions involved the use of Tf2O and 2-chloropyridine and isocyanates are likely to be key intermediates. The method was extended to substrates bearing less nucleophilic aryl moieties by using Lewis acid additives, such as BF3· Et2O, to enhance the Friedel-Crafts-type cyclization of the isocyanate intermediates. This method allowed the synthesis of various substituted isoquinolin-1-ones, β-carbolines, thiophene-fused ring systems and tetrahydrobenzoazepin-1-ones in good yields and with high regioselectivities. Copyright

17α-HYDROXYLASE/C17,20-LYASE INHIBITORS

The present invention provides compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, A and n are as defined herein. A deuteriated derivative of the compound of Formula (I) is also provided.