34844-51-4Relevant academic research and scientific papers
Cyclodehydration of fluorinated diols using the mitsunobu reaction: Highly efficient synthesis of trifluoromethylated cyclic ethers
Prakash, G. K. Surya,Do, Clement,Wang, Fang,Mathew, Thomas,Olah, George A.
experimental part, p. 1891 - 1898 (2010/08/20)
Synthesis of trifluoromethylated cyclic ethers has been achieved via the Mitsunobu cyclodehydration of fluorinated diols with high efficacy. The methodology is found to be widely applicable to the synthesis of cyclic ethers with varying ring size (3-7) fr
The cross-aldol reaction of hexafluoroacetone (HFA) with ketones catalyzed by an acid
Komata, Takeo,Matsunaga, Kei,Hirotsu, Yoshiki,Akiba, Shinya,Ogura, Katsuyuki
, p. 902 - 909 (2008/03/14)
The cross-aldol reactions of hexafluoroacetone (HFA) and ketones using an acid catalyst are reported. When concentrated sulfuric acid was employed as the catalyst, HFA reacted regioselectively with various ketones at 50-100 °C to give the aldol adducts (6) in good yields. The reaction is initiated by an acid-catalyzed transformation of the ketone into the corresponding enol that reacts with HFA. The obtained adducts (6) can be reduced with hydrogen under a Ru/C catalyst to lead to the corresponding fluorine-containing diols (13).
Process for producing fluorine-containing diol and its derivatives
-
Page/Page column 6-7, (2008/06/13)
A process for producing a fluorine-containing diol represented by the formula [2], includes reducing a hydroxy ketone represented by the formula [1], by hydrogen in the presence of a ruthenium catalyst. The ruthenium catalyst may be a solid-phase catalyst
Facile preparation and synthetic applications of LiCH2C(CF3)2Oli
Grushin, Vladimir V.,Marshall, William J.,Halliday, Gary A.,Davidson, Fredric,Petrov, Viacheslav A.
, p. 121 - 129 (2007/10/03)
Bromohydrin BrCH2C(CF3)2OH readily reacts with two equivalents of n-BuLi at - 78 °C to produce the corresponding dilithium derivative LiCH2C(CF3)2OLi in high yield. This dilithiated derivative reacts selectively, acting as a C-nucleophile, with a variety of electrophiles such as R2PCl, carbonyl compounds, and epoxides, to give electron-deficient phosphines R2PCH2C(CF3)2OH, 1,3- and 1,4-diols, correspondingly.
