731-00-0

Usage

InChI:InChI=1/C11H8F6O2/c12-10(13,14)9(19,11(15,16)17)6-8(18)7-4-2-1-3-5-7/h1-5,19H,6H2

Upstream product

• 4577-41-7 1,1,1-trifluoro-4-phenyl-2-(trifluoromethyl)but-3-yn-2-ol 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 684-16-2 Hexafluoroacetone 
• 6738-06-3 phenylethynylmagnesium bromide 
• 98-86-2 acetophenone 
• 7196-01-2 4-(1-phenylvinyl)morpholine 
• 143211-22-7 4,4,4-Trifluoro-1-phenyl-3-trifluoromethyl-3-trimethylsilanyloxy-butan-1-one 

Downstream Products

• 35443-84-6 4,4,4-trifluoro-1-phenyl-3-(trifluoromethyl)but-2-en-1-one 
• 34844-51-4 1-phenyl-4,4,4-trifluoro-3-(trifluoromethyl)butane-l,3-diol 
• 923018-85-3 1-cyclohexyl-4,4,4-trifluoro-3-(trifluoromethyl)butane-l,3-diol 

Relevant academic research and scientific papers

Efficient and convenient entry to β-hydroxy-β-trifluoromethyl-β-substituted ketones and 2,6-disubstituted 4-trifluoromethylpyridines based on the reaction of trifluoromethyl ketones with enamines or imines

The reactions of trifluoromethyl ketones with enamines or imines are described. The reaction of trifluoroacetone with enamines or imines followed by hydrolysis gave the corresponding β-hydroxyβ-trifluoromethyl-β-methyl ketones in good yields. The reaction

New nucleophilic rearrangement in the mechanism of the three-component domino cyclisation affording fluoroalkylated (pyrrolo)quinazolines

The following mechanism steps were verified for the three-component domino cyclisation affording (pyrrolo)quinazolines from 2-(aminomethyl)aniline, a very reactive oxo compound and "usual" oxo compound. The first step was a rapid reaction of very reactive oxo compound (trifluoropyruvate or hexafluoroacetone) with benzylic amino group to form hemiaminal, but not imine; the second step was the reaction of oxo compound with aromatic amino group to form imine (Schiff base) being in equilibrium with its enamine form; the third step was an intramolecular attack of the hemiaminal carbon by the enamine carbon followed by a new nucleophilic rearrangement to form tetrahydropyrimidine cycle; the forth step was closure of the lactam ring, if ester group was available as in trifluoropyruvate.2013 Elsevier B.V. All rights reserved.

Fluorinated alkoxy-imino catalyst components

This invention relates to fluorinated alkoxy-imino metallic complexes and their use in catalyst systems for the polymerisation or oligomerisation of ethylene and alpha-olefins.

Convenient synthesis of mono- and di-β-hydroxy-β-bis(trifluoromethyl)-(di)imines from β-hydroxy-β-bis(trifluoromethyl)-ketones and (di)amines

A series of novel β-hydroxy-β-bis(trifluoromethyl)-imines (2a-j) and di(β-hydroxy-β-bis(trifluoromethyl))-diimines (3a-f) were prepared in moderate to good yields via a simple two-step approach: first, β-hydroxy-β-bis(trifluoromethyl)-ketones (1a-c) were

The cross-aldol reaction of hexafluoroacetone (HFA) with ketones catalyzed by an acid

The cross-aldol reactions of hexafluoroacetone (HFA) and ketones using an acid catalyst are reported. When concentrated sulfuric acid was employed as the catalyst, HFA reacted regioselectively with various ketones at 50-100 °C to give the aldol adducts (6) in good yields. The reaction is initiated by an acid-catalyzed transformation of the ketone into the corresponding enol that reacts with HFA. The obtained adducts (6) can be reduced with hydrogen under a Ru/C catalyst to lead to the corresponding fluorine-containing diols (13).

Processes for producing fluorine-containing 2,4-diols and their derivatives

A process for producing a fluorine-containing 2,4-diol represented by the formula [4], wherein R1 represents a hydrogen atom or an acyclic or cyclic alkyl group having a carbon atom number of 1 to 7; R2 represents an acyclic or cyclic alkyl group having a carbon atom number of 1 to 7, a phenyl group, or a substituted phenyl group; and R1 and R2 are optionally bonded to each other to form a ring, includes reducing a hydroxy ketone represented by the formula [3], wherein R1 and R2 are defined as above, by hydrogen in the presence of a ruthenium catalyst.

Synthese von 4,4-Bis(trifluormethyl)-1-oxabuta-1,3-dienen

Silyl enol ethers (1) and hexafluoroacetone (2) react to give O-silylated aldol adducts 3 which, after desilylation with methanol/hydrochloric acid, are transformed into 4,4-bis(trifluoromethyl)-1-oxabuta-1,3-dienes (5) on treatment with trifluoroacetic a

REGIOSPECIFIC α-HEXAFLUOROISOPROPYLIDENATION OF KETONES USING HEXAFLUOROACETONE

Hexafluoroacetone (HFA) reacted regiospecifically with various enol silyl ethers at -30 to -35 deg C in the presence of a Lewis acid to give HFA aldols, or α-bis(trifluoromethyl)hydroxymethyl carbonyl compounds, in good yields.The reaction of HFA with die