34855-33-9

Basic information

• Product Name: 4-bromo-N-(4-bromophenyl)benzamide
• Synonyms: 4-bromo-N-(4-bromophenyl)benzamide
• CAS NO: 34855-33-9
• Molecular Formula: C₁₃H₉Br₂NO
• Molecular Weight: 355.02466
• Mol File: 34855-33-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 347.3°C at 760 mmHg
• Flash Point: 163.8°C
• Appearance: /
• Density: 1.769g/cm³
• Vapor Pressure: 5.43E-05mmHg at 25°C
• Refractive Index: 1.684
• CAS DataBase Reference: 4-bromo-N-(4-bromophenyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-N-(4-bromophenyl)benzamide(34855-33-9)
• EPA Substance Registry System: 4-bromo-N-(4-bromophenyl)benzamide(34855-33-9)

Safety Data

• Hazardous Substances Data: 34855-33-9(Hazardous Substances Data)

Usage

General Description

4-Bromo-N-(4-bromophenyl)benzamide is a chemical compound that belongs to the benzamide class of organic compounds. It is a derivative of benzamide with a bromine atom and a 4-bromophenyl substitution at the nitrogen and carbon positions, respectively. 4-Bromo-N-(4-bromophenyl)benzamide is often used in pharmaceutical research as a building block for the synthesis of various biologically active compounds. It can also be used as an intermediate in the production of agrochemicals, dyes, and other fine chemicals. The presence of bromine in its structure makes it suitable for Suzuki-Miyaura coupling reactions, which are widely used in the synthesis of complex organic molecules.

InChI:InChI=1/C13H9Br2NO/c14-10-3-1-9(2-4-10)13(17)16-12-7-5-11(15)6-8-12/h1-8H,(H,16,17)

Upstream product

• 3988-03-2 bis(4-bromophenyl)methanone 
• 99821-96-2 bis(4-bromophenyl)methanimine 
• 106-41-2 4-bromo-phenol 
• 201230-82-2 carbon monoxide 
• 66107-30-0 4-bromophenyl trifluoromethanesulfonate 
• 106-40-1 4-bromo-aniline 
• 3470-38-0 1,3-bis-(4-bromo-phenyl)-triazene 
• 586-75-4 4-chlorobenzoyl chloride 
• 586-76-5 4-Bromobenzoic acid 
• 60-29-7 diethyl ether 
• 10026-13-8 phosphorus pentachloride 
• 96462-96-3 bis(4-bromophenyl)methanone oxime 
• 1122-91-4 4-bromo-benzaldehyde 

Relevant articles and documents

Microdroplets as Microreactors for Fast Synthesis of Ketoximes and Amides

The formation of amide bonds is one of the most valuable transformations in organic synthesis. Beckmann rearrangement is a well-known method for producing secondary amides from ketoximes. This study demonstrates the rapid synthesis of ketoximes and amides in microdroplets. Many factors are found to affect the yield, such as microdroplet generation devices, temperature, catalysts, and concentrations of reactants. In particular, the temperature has a great influence on the synthesis of amide, which is demonstrated by a sharp ascendance to the yield when the temperature was increased to 45 °C. The best amide yield (93.3%) can be obtained by using coaxial flowing devices, a sulfonyl chloride compound as a catalyst, and heating to 55 °C in microdroplets. The yields can reach 78.7-91.3% for benzoylaniline and 87.2-93.4% for benzophenone oximes in several seconds in microdroplets compared to 10.1-66.1% and 82.5-93.3% in several hours in the bulk phase. Apart from the dramatically decreased reaction time and enhanced reaction yields, the microdroplet synthesis is also free of severe reaction environments (anhydrous and anaerobic conditions). In addition, the synthesis in microdroplets also saves reactants and solvents and reduces the waste amounts. All of these merits indicate that the microdroplet synthesis is a high-efficiency green methodology.

Hypervalent Iodine-Mediated Oxidative Rearrangement of N-H Ketimines: An Umpolung Approach to Amides

An umpolung approach to amides via hypervalent iodine-mediated oxidative rearrangement of N-H ketimines under mild reaction conditions is described. This strategy provides target amides with excellent selectivity in good yields. In addition, preliminary m

Palladium-Catalyzed Carbonylative Synthesis of Amides from Aryltriazenes under Additive-Free Conditions

An interesting palladium-catalyzed carbonylative synthesis of amides from aryltriazenes was developed. By using Pd(MeCN2)Cl2 as the catalyst precursor under CO pressure through a N2 extrusion/CO insertion sequence, a broad range of aryltriazenes were transformed into the corresponding amides in good yields with excellent functional group tolerance. Remarkably, no additives such as acids or phosphine ligands were required.