34857-71-1

Basic information

• Product Name: Carbamic acid, diethyl-, 4-(trifluoromethyl)phenyl ester
• CAS NO: 34857-71-1
• Molecular Formula: C12H14F3NO2
• Molecular Weight: 261.244
• Mol File: 34857-71-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Carbamic acid, diethyl-, 4-(trifluoromethyl)phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, diethyl-, 4-(trifluoromethyl)phenyl ester(34857-71-1)
• EPA Substance Registry System: Carbamic acid, diethyl-, 4-(trifluoromethyl)phenyl ester(34857-71-1)

Safety Data

• Hazardous Substances Data: 34857-71-1(Hazardous Substances Data)

Upstream product

• 124-38-9 carbon dioxide 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 109-89-7 diethylamine 
• 402-45-9 4-hydroxybenzotrifluoride 
• 88-10-8 N,N-diethylcarbamyl chloride 

Downstream Products

• 1646630-04-7 N,N-diethyl-2-hydroxy-5-(trifluoromethyl)benzamide 
• 67589-15-5 1-(2-hydroxy-5-(trifluoromethyl)phenyl)ethan-1-one 
• 25371-98-6 N-(4-trifluoromethylphenyl)imidazole 
• 1282034-12-1 N-butyl-N-methyl-4-(trifluoromethyl)benzenamine 
• 113845-68-4 1-(4(-trifluoromethyl)phenyl)pyrrolidine 
• 113845-69-5 4-(4-trifluoromethylphenyl)morpholine 
• 1245824-48-9 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-trifluoromethylphenyl N,N-diethylcarbamate 

Relevant articles and documents

Oxidative Addition of Aryl Electrophiles to a Prototypical Nickel(0) Complex: Mechanism and Structure/Reactivity Relationships

Detailed kinetic studies of the reaction of a model Ni0 complex with a range of aryl electrophiles have been conducted. The reactions proceed via a fast ligand exchange pre-equilibrium, followed by oxidative addition to produce either [NiIX(dppf)] (and biaryl) or [NiII(Ar)X(dppf)]; the ortho substituent of the aryl halide determines selectivity between these possibilities. A reactivity scale is presented in which a range of substrates is quantitatively ranked in order of the rate at which they undergo oxidative addition. The rate of oxidative addition is loosely correlated to conversion in prototypical cross-coupling reactions. Substrates that lead to NiI products in kinetic experiments produce more homocoupling products under catalytic conditions.

A copper-catalyzed oxidative coupling reaction of arylboronic acids, amines and carbon dioxide using molecular oxygen as the oxidant

A Cu-catalyzed oxidative coupling reaction of arylboronic acids, amines and carbon dioxide is described for the first time in this paper. The reaction tolerates a wide range of functional groups, providing a convenient protocol for the synthesis of various O-aryl carbamates. The successful development of the transformation was enabled by the use of BF3·OEt2 as the promoter and molecular oxygen as the oxidant. Mechanistic studies suggested that the CuII carbamato complex is involved in the catalytic transformation.

Lithiation of a silyl ether: Formation of an ortho-fries hydroxyketone

A hydroxy-directed alkylation of an N,N-diethylarylamide using CIPE-assisted α-silyl carbanions (CIPE=complex-induced proximity effect) has been developed using a simple reagent combination of LDA (lithium diisopropylamide) and chlorosilane. A study of the mechanism, and the application of the procedure to an anionic Snieckus-Fries rearrangement for a highly efficient synthesis of the potent phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002, are reported.