34883-14-2Relevant academic research and scientific papers
A novel 6-benzyl ether benzoxaborole is active against mycobacterium tuberculosis in vitro
Patel, Nipul,O’Malley, Theresa,Zhang, Yong-Kang,Xia, Yi,Sunde, Bjorn,Flint, Lindsay,Korkegian, Aaron,Ioerger, Thomas R.,Sacchettini, Jim,Alley,Parish, Tanya
, (2017)
We identified a novel 6-benzyl ether benzoxaborole with potent activity against Mycobacterium tuberculosis. The compound had an MIC of 2 μM in liquid medium. The compound was also able to prevent growth on solid medium at 0.8 μM and was active against intracellular bacteria (50% inhibitory concentration [IC50] 3.6 μM) without cytotoxicity against eukaryotic cells (IC50 100 μM). We isolated resistant mutants (MIC ≥ 100 μM), which had mutations in Rv1683, Rv3068c, and Rv0047c.
A benzaldehyde derivative obtained from Hypoxylon truncatum NBRC 32353 treated with hygromycin B
Kamauchi, Hitoshi,Suzuki, Mitsuaki,Takao, Koichi,Sugita, Yoshiaki
, (2021/12/09)
The ribosome-targeted antifungal agent hygromycin B (HygB) alters the secondary metabolite profiles of fungi. Hypoxylon truncatum NBRC 32353 fermented in the presence of hygromycin B in barley medium activated secondary metabolite synthesis. A new benzaldehyde derivative truncaaldehyde (1) was obtained, along with thirteen known compounds (2–14). The structures of the new compounds were revealed using NMR and single-crystal X-ray crystallography. The total synthesis of (±)-1 was achieved using a four-step sequence, and chiral separation was accomplished. The isolated compounds were tested for their monoamine oxidase (MAO) -A and -B inhibitory activities, with six compounds ((±)-1, 4, 5, 7, 8, and 10) showing inhibitory activity.
1 -HYDROXY-BENZOOXABOROLES AS ANTIPARASITIC AGENTS
-
, (2014/10/03)
Provided are compounds useful for controlling endoparasites both in animals and agriculture. Further provided are methods for controlling endoparasite infestations of an animal by administering an effective amount of a compound as described above, or a pharmaceutically acceptable salt thereof, to an animal, as well as formulations for controlling endoparasite infestations using the compounds described above or an acceptable salt thereof, and an acceptable carrier. The claimed compounds are described by the following Markush formula:A typical example for a compound according to above formula is: A typical example for a compound according to above formula is:
