17636-16-7

Upstream product

• 56410-44-7 benzyl 2-hydroxy-4-((2-hydroxy-4-methoxy-3,6-dimethylbenzoyl)oxy)-3,6-dimethyl benzoate 
• 31581-32-5 ethyl 2,4-dihydroxy-3,6-dimethylbenzoate 
• 479-26-5 2-hydroxy-4-methoxy-3,6-dimethylbenzoic acid 
• 56410-32-3 4-benzyloxy-2-hydroxy-3,6-dimethylbenzoic acid 
• 69336-17-0 methyl 4-(benzyloxy)-2-hydroxy-3,6-dimethylbenzoate 
• 4707-47-5 2,4-dihydroxy-3,6-dimethyl-benzoic acid methyl ester 
• 19104-04-2 methyl 2-hydroxy-4-methoxy-3,6-dimethylbenzoate 
• 4707-46-4 2,4-dihydroxy-3,6-dimethylbenzoic acid 
• 56410-30-1 benzyl 2,4-dihydroxy-3,6-dimethylbenzoate 

Downstream Products

• 261174-55-4 2-hydroxy-4-(2-hydroxy-4-methoxy-3,6-dimethyl-benzoyloxy)-3,6-dimethyl-benzoic acid ethyl ester 
• 19104-04-2 methyl 2-hydroxy-4-methoxy-3,6-dimethylbenzoate 
• 488-87-9 2,5-dimethyl-1,3-benzenediol 
• 56410-33-4 ethyl 2-hydroxy-4-methoxy-3,6-dimethylbenzoate 
• 4707-46-4 2,4-dihydroxy-3,6-dimethylbenzoic acid 
• 71309-88-1 tert-butyl rhizonate 
• 15719-64-9 methylammonium carbonate 
• 34883-14-2 2,4-dihydroxy-3,6-dimethylbenzaldehyde 
• 61621-48-5 4,6-dibromo-2,5-dimethyl-resorcinol 
• 124-38-9 carbon dioxide 
• 74-88-4 methyl iodide 
• 479-26-5 2-hydroxy-4-methoxy-3,6-dimethylbenzoic acid 
• 5014-22-2 methyl barbatate 

Relevant academic research and scientific papers

Synthesis of barbacic acid

A new approach for the synthesis of the active barbatic acid has been achieved in eight steps with 22.3% total yield by using commercially available methyl atratate as starting material. This synthesis provides access to multi-gram quantities of barbatic

Depsides as non-redox inhibitors of leukotriene B4 biosynthesis and HaCaT cell growth. 1. Novel analogues of barbatic and diffractaic acid

A series of barbatic and diffractaic acid analogues has been synthesized and evaluated as inhibitors of leukotriene B4 (LTB4) biosynthesis and as antiproliferative agents. The 4-O-demethyl barbatic and diffractaic acid derivatives were among the most active compounds in both assays. In particular, ethyl 4-O-demethylbarbatate was the most potent LTB4 biosynthesis inhibitor of this series, with an IC50 value in the submicromolar range. Because the compounds did not show appreciable reactivity against a stable free radical, 2,2-diphenyl-1-picrylhydrazyl, and did not produce appreciable amounts of deoxyribose degradation as a measure of their potency to generate hydroxyl radicals, a simple redox effect could not explain their biological activity. Also, there was no nonspecific cytotoxicity as documented by the activity of lactate dehydrogenase released from the cytoplasm of keratinocytes, which was in the control range.