34932-32-6Relevant academic research and scientific papers
Catalyst and solvent switched divergent C-H functionalization: Oxidative annulation of: N -aryl substituted quinazolin-4-amine with alkynes
Meesa, Siddi Ramulu,Naikawadi, Praveen Kumar,Gugulothu, Kishan,Shiva Kumar
, p. 3032 - 3037 (2020/05/08)
The development of site-selective C-H functionalizations/annulations is one of the most challenging practices in synthetic organic chemistry particularly for substrates bearing several similarly reactive C-H bonds. Herein, we describe catalyst and solvent controlled ortho/peri site-selective oxidative annulation of C-H bonds of N-aryl substituted quinazolin-4-amines with internal alkynes. The ortho C-H selective annulation was observed using Pd-catalyst in DMF to give indole-quinazoline derivatives, while, Ru-catalyst in PEG-400 favoured the peri C-H bond annulation exclusively to furnish pyrido-quinazoline derivatives.
Cu/ N, N′-Dibenzyloxalamide-Catalyzed N-Arylation of Heteroanilines
Chen, Zhixiang,Ma, Dawei
supporting information, p. 6874 - 6878 (2019/09/07)
N,N′-Dibenzyloxalamide (DBO) was identified as a powerful ligand for promoting Cu-catalyzed coupling of heteroanilines with (hetero)aryl halides. For (hetero)aryl chlorides, the coupling reaction occurred at 130 °C with 5 mol % CuBr and 10 mol % DBO. For
Amination of heteroaryl chlorides: Palladium catalysis or SNAr in green solvents?
Walsh, Katie,Sneddon, Helen F.,Moody, Christopher J.
, p. 1455 - 1460 (2013/09/12)
The reaction of heteroaryl chlorides in the pyrimidine, pyrazine and quinazoline series with amines in water in the presence of KF results in a facile SNAr reaction and N-arylation. The reaction is less satisfactory with pyridines unless an add
An efficient HCCP-mediated direct amination of quinazolin-4(3H)-ones
Shen, Zhenlu,He, Xiaofei,Dai, Jialiang,Mo, Weimin,Hu, Baoxiang,Sun, Nan,Hu, Xinquan
experimental part, p. 1665 - 1672 (2011/04/15)
An efficient direct amination of quinazolin-4(3H)-ones has been developed. Treatment of quinazolin-4(3H)-ones with HCCP, DIPEA, and N-contained nucleophiles in acetonitrile could be able to form the corresponding 4-aminoquinazoline derivatives. Under the
