349404-48-4Relevant academic research and scientific papers
Amidation of unactivated ester derivatives mediated by trifluoroethanol
McPherson, Christopher G.,Caldwell, Nicola,Jamieson, Craig,Simpson, Iain,Watson, Allan J. B.
, p. 3507 - 3518 (2017/04/26)
A catalytic amidation protocol mediated by 2,2,2-trifluoroethanol has been developed, facilitating the condensation of unactivated esters and amines, furnishing both secondary and tertiary amides. The complete scope and limitations of the method are described, along with modified conditions for challenging substrates such as acyclic secondary amines and chiral esters with retention of chiral integrity.
2-Trifluoroacetylthiophenes, a novel series of potent and selective class II histone deacetylase inhibitors
Jones, Philip,Bottomley, Matthew J.,Carfi, Andrea,Cecchetti, Ottavia,Ferrigno, Federica,Lo Surdo, Paola,Ontoria, Jesus M.,Rowley, Michael,Scarpelli, Rita,Schultz-Fademrecht, Carsten,Steinkuehler, Christian
scheme or table, p. 3456 - 3461 (2009/04/05)
The identification of class II HDAC inhibitors has been hampered by lack of efficient enzyme assays, in the preceding paper two assays have been developed to improve the efficiency of these enzymes: mutating an active site histidine to tyrosine, or by the
