349410-58-8

Basic information

• Product Name: 2-(4-nitrophenyl)-1-(4-phenylpiperazin-1-yl)ethanone
• Synonyms: 2-(4-nitrophenyl)-1-(4-phenylpiperazin-1-yl)ethanone
• CAS NO: 349410-58-8
• Molecular Weight: 325.367
• Mol File: 349410-58-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(4-nitrophenyl)-1-(4-phenylpiperazin-1-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-nitrophenyl)-1-(4-phenylpiperazin-1-yl)ethanone(349410-58-8)
• EPA Substance Registry System: 2-(4-nitrophenyl)-1-(4-phenylpiperazin-1-yl)ethanone(349410-58-8)

Safety Data

• Hazardous Substances Data: 349410-58-8(Hazardous Substances Data)

Usage

Physical appearance

Yellow crystalline solid.

Molecular weight

349.38 g/mol.

Usage

Commonly used in pharmaceuticals and organic synthesis.

Chemical structure

Consists of a nitrophenyl group and a phenylpiperazine group attached to an ethanone moiety.

Applications

Development and production of various pharmaceuticals.

Additional uses

Utilized in research laboratories for further chemical studies and experiments.

Upstream product

• 92-54-6 4-phenyl-1-piperazine 
• 104-03-0 4-nitrobenzeneacetic acid 
• 1877-73-2 3-nitro-benzeneacetic acid 

Downstream Products

• 1382482-00-9 2-phenyl-N-{4-[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-acetamide 
• 1382482-01-0 N-{4-[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-pyridin-2-yl-acetamide 
• 1382482-02-1 N-{4-[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-pyridin-3-yl-acetamide 
• 1382482-03-2 N-{4-[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-pyridin-4-yl-acetamide 
• 1382482-04-3 1-phenyl-3-{4-[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-urea 
• 1382482-05-4 1-{4-[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-pyridin-2-yl-urea 
• 1382482-06-5 1-{4-[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-pyridin-3-yl-urea 
• 1382482-07-6 1-{4-[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-pyridin-4-yl-urea 
• 93995-98-3 1-[2-(4-nitrophenyl)ethyl]-4-phenylpiperazine 
• 139153-32-5 4-[2-(4-phenylpiperazin-1-yl)ethyl]phenylamine 
• 1369303-80-9 1-[2-(3-nitrophenyl)ethyl]-4-phenylpiperazine 

Relevant articles and documents

ARYLALKYLPIPERAZINES FOR USE AS NEUROPROTECTIVE AGENTS

A compound of the general formula A or a or a pharmaceutically acceptable salt or solvate thereof, wherein: R1 is selected from the group consisting of: C1-C12-alkyl, C3-C12-cycloalkyl, C6-

Interactions of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-yl- acetamides and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas with dopamine D2 and 5-hydroxytryptamine 5HT1A receptors

It is suggested that the ratio of dopamine D2 to 5-hydroxytryptamine 5-HT1A activity is an important parameter that determines the efficiency of antipsychotic drugs. Here we present the synthesis of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-yl-acetamides and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas and their structure-activity relationship studies on dopamine D2 and 5-hydrohytryptamine 5-HT1A receptors. It was shown that ligand selectivity and affinity strongly depends on their topology and the presence of a pyridyl group in the head of molecules. Molecular modeling studies using homology modeling and docking simulation revealed a rational explanation for the ligand behavior. The observed binding modes and receptor-ligand interactions provided us with a clue for optimizing the optimal selectivity towards 5-HT 1A receptors.