93995-98-3

Upstream product

• 92-54-6 4-phenyl-1-piperazine 
• 1369303-78-5 2-(3-nitrophenyl)-1-(4-phenylpiperazin-1-yl)ethanone 
• 349410-58-8 2-(4-nitrophenyl)-1-(4-phenylpiperazin-1-yl)ethanone 

Downstream Products

• 1018265-20-7 3-[2-(4-phenylpiperazin-1-yl)ethyl]phenylamine 
• 139153-32-5 4-[2-(4-phenylpiperazin-1-yl)ethyl]phenylamine 
• 1382482-01-0 N-{4-[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-pyridin-2-yl-acetamide 
• 1382482-00-9 2-phenyl-N-{4-[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-acetamide 

Relevant academic research and scientific papers

ARYLALKYLPIPERAZINES FOR USE AS NEUROPROTECTIVE AGENTS

A compound of the general formula A or a or a pharmaceutically acceptable salt or solvate thereof, wherein: R1 is selected from the group consisting of: C1-C12-alkyl, C3-C12-cycloalkyl, C6-

ARYLPIPERAZINES AS NEUROPROTECTIVE AGENTS

The present invention generally relates to novel arylpiperazines. In particular, these arylpiperazines can be used as neuroprotective agents. The invention also relates to a process for the manufacture of the novel compounds. Further, the invention relates to the use of the novel arylpiperazines in the treatment of diseases associated with, accompanied by or caused by mitochondrial stress.

Interactions of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-yl- acetamides and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas with dopamine D2 and 5-hydroxytryptamine 5HT1A receptors

It is suggested that the ratio of dopamine D2 to 5-hydroxytryptamine 5-HT1A activity is an important parameter that determines the efficiency of antipsychotic drugs. Here we present the synthesis of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-yl-acetamides and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas and their structure-activity relationship studies on dopamine D2 and 5-hydrohytryptamine 5-HT1A receptors. It was shown that ligand selectivity and affinity strongly depends on their topology and the presence of a pyridyl group in the head of molecules. Molecular modeling studies using homology modeling and docking simulation revealed a rational explanation for the ligand behavior. The observed binding modes and receptor-ligand interactions provided us with a clue for optimizing the optimal selectivity towards 5-HT 1A receptors.

Synthesis and class III type antiarrhythmic activity of 4-Aroyl (and Aryl)-1-aralkylpiperazines

The synthesis and in vitro Class III antiarrhythmic activity of several 4-aroyl (and aryl)-1-aralkylpiperazine and piperidine derivatives are described. Among several potent compounds identified in the series, RWJ-28810 (3), with its EC20 of 3 nM, ranks as one of the most potent (in vitro) compounds reported. (C) 2000 Elsevier Science Ltd.