34960-41-3Relevant academic research and scientific papers
Compound with dual inhibitory activity TDO, IDOO1 and application of compound for treating neurodegenerative disease (by machine translation)
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Paragraph 0149; 0221-0224, (2020/10/06)
The present invention provides a compound of formula I, or a pharmaceutically acceptable salt thereof, or a solvate thereof, which can selectively inhibit TDO, IDOO1, which has a significant inhibitory effect on TDO and/or IDOO1. In addition, the prepared compound has a remarkable anti-tumor effect, has a certain treatment effect on's disease and's disease, and has a good application prospect in the field of medicine preparation. (by machine translation)
Regioselective silver-mediated Kondakov-Darzens olefin acylation
Barczak, Nicholas T.,Jarvo, Elizabeth R.
supporting information; experimental part, p. 12912 - 12916 (2011/12/04)
Enone construction: A silver-mediated olefin acylation reaction is described, in which five-, six-, and -seven-membered rings, tetrasubstituted olefins, bridged bicycles, spirocycles, and benzoxepinones are prepared. Highly selective intermolecular reactions are coupled to a Nazarov cyclization for the effective preparation of cyclopentenones, including the core of modhephene (see scheme). Copyright
cis-dihydroxylation of unsaturated potassium alkyl- and aryltrifluoroborates
Molander, Gary A.,Figueroa, Ruth
, p. 75 - 78 (2007/10/03)
(Chemical Equation Presented) The cis-dihydroxylation of olefin-containing potassium alkyl- and aryltrifluoroborates proceeds readily in moderate to excellent yields. The resulting diols are efficient coupling partners in Suzuki-Miyaura-type reactions wit
Free-radical based cycloalkanol synthesis and annulation from thioacetal precursors
Yadav, Veejendra,Fallis, Alex G.
, p. 779 - 789 (2007/10/02)
A general procedure for the synthesis of diverse cyclopentanols via free-radical cyclization of unsaturated 1,3-oxathiolanes and 1,3-oxathiolan-5-ones is described.The scope of these reactions, including preliminary rate studies that indicate that the 1,3-oxathiolan-5-ones cyclize at a useful rate (1.4*106 M-1s-1 at 80 deg C), has been examined.This permits the rapid assembly, by intramolecular annulation, of various additional ring systems, including bicyclooctanols, bicyclononanols, and bicyclooctanols for use in total synthesis. Key words: radical cyclization, oxathiolanes, oxathiolanones.
REACTION OF (TRIMETHYLSTANNYL)COPPER(I) REAGENTS WITH α,β-ACETYLENIC ESTERS. STEREOCONTROLLED SYNTHESIS OF ALKYL (E)- AND (Z)-3-TRIMETHYLSTANNYL-2-ALKENOATES
Piers, Edward,Chong, Michael J.,Morton, Howard E.
, p. 363 - 380 (2007/10/02)
The reactions of α,β-acetylenic esters 1 with the (trimethylstannyl)copper(I) reagents 4-7 provide good to excellent yields of the corresponding β-trimethylstannyl α,β-unsaturated esters 10 and (or) 11.In nearly all cases studied, except for the reactions
Cycloalkylmethyl Radicals. Part 4. Electron Spin Resonance Study of Conformational Equilibria in Cyclohexenylmethyl and 4-Alkylcyclohexenylmethyl Radicals
Walton, John C.
, p. 1641 - 1646 (2007/10/02)
For cyclohex-2-enylmethyl and 4-alkoxycyclohex-2-enylmethyl radicals the quasi-axial and the quasi-equatorial conformers can both be observed by e.s.r. spectroscopy.Similary, the axial and equatorial conformers of cyclohex-3-enylmethyl radical can be distinguished by e.s.r. spectroscopy.The conformational free-energy difference of the CH2. group in the 2-position, -ΔGdeg300, was found to be 0.17 +/- 0.03 kcal mol-1 and in the 3-position -ΔGdeg300=0.0 +/- 0.1 kcal mol-1.The Arrhenius parameters for inversion of the half-chair conformation of cyclohex-2-enylmethyl radical were determined by lineshape analysis of the exchange-broadened spectra and found to be: log(kf/s-1)=12.3 - (5.7 kcal mol-1)/2.3RT and log(kb/s-1)=12.0 - (5.5 kcal mol-1)/2.3RT.The barrier to rotation about the C.α-Cβ bond in a cyclohexenylmethyl radicals is much less than the barrier in a cyclohexylmethyl radical because the former radical has only one syn-axial hydrogen on C(5) to impede the rotation whereas the latter radical has two syn-axial hydrogens on C(3) and C(5).
Methylenecyclohexenes: inversion barriers from the far-infrared spectra
Smithson, Tracy L.,Ibrahim, Nan,Wieser, Hal
, p. 442 - 453 (2007/10/02)
The far-infrared spectra of 3-methylenecyclohexene, 4-methylenecyclohexene, and 1-methyl-3-methylenecyclohexene in the region of 80-400 cm-1 are reported and interpreted mainly with a view to the two lowest out-of-plane deformations of the cycl
