349644-07-1

Usage

Uses

Used in Organic Chemistry:
1-(4-Fluorobenzoyl)pyrrolidine is used as a synthetic intermediate for the preparation of various organic compounds. Its fluorobenzoyl group can participate in specific chemical reactions, making it a valuable building block for the synthesis of more complex organic molecules.
Used in Pharmaceutical Applications:
Due to its structural similarity to other biologically active compounds, 1-(4-Fluorobenzoyl)pyrrolidine may have potential pharmaceutical applications. The fluorobenzoyl group could impart specific properties to the molecule, such as enhanced bioactivity or selectivity, which can be exploited in the development of new drugs.
Used in Chemical Reactions:
1-(4-Fluorobenzoyl)pyrrolidine is used as a reactant in specific chemical reactions, where the fluorobenzoyl group can be selectively modified or replaced to generate new compounds with desired properties. This versatility makes it a valuable tool in the field of organic chemistry.

InChI:InChI=1/C11H12ClNO/c12-10-5-3-9(4-6-10)11(14)13-7-1-2-8-13/h3-6H,1-2,7-8H2

Upstream product

• 123-75-1 pyrrolidine 
• 459-56-3 4-fluorobenzylic alcohol 
• 456-22-4 4-Fluorobenzoic acid 

Downstream Products

• 1122658-55-2 (2,3-dihydro-1H-pyrrol-1-yl)(4-fluorophenyl)methanone 
• 1766-85-4 1-(4-fluorophenyl)-1-heptanone 
• 1446279-80-6 (E)-(4-fluoro-2-(prop-1-en-1-yl)phenyl)(pyrrolidin-1-yl)methanone 

Relevant academic research and scientific papers

Direct dehydrogenative amide synthesis from alcohols and amines catalyzed by γ-alumina supported silver cluster

The heterogeneously catalyzed reaction of alcohols with amines to form amides and H2 using the easily prepared and inexpensive heterogeneous catalyst, Ag/Al2O3 has been reported. Aromatic and aliphatic amides are functiona

Synthesis of α-Aminosilanes by 1,2-Metalate Rearrangement Deoxygenative Silylation of Aromatic Amides

An efficient nickel-catalyzed deoxygenative silylation reaction of aromatic amides with silylboranes in the presence of a Sm/SmI2system for the construction of α-aminosilanes is described. This strategy provides a direct method for synthesizing α-aminosilanes with high efficiency and good functional group compatibility and includes readily accessible starting materials and valuable products.

SUBSTITUTED PIPERIDINES AS HISTAMINE H3 RECEPTOR LIGANDS

The present invention relates to novel piperidine ether derivatives having affinity for the histamine H3 receptor, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.