1766-85-4

Usage

Aromatic ketone

It is a type of organic compound that consists of an aromatic ring (a benzene ring) and a ketone functional group (C=O).

Seven-carbon chain

The compound has a straight chain of seven carbon atoms.

Fluorine-substituted phenyl group

A fluorine atom is attached to the phenyl group (a six-carbon ring with alternating single and double bonds) in the compound.

Wide range of applications

1-Heptanone, 1-(4-fluorophenyl)is used in various industries, such as pharmaceuticals, flavors and fragrances, and as a solvent in organic synthesis.

Characteristic odor

The compound is known for its distinct smell, which is utilized in the flavor and fragrance industry.

Flavoring agent in the food industry

Due to its unique aroma, 1-Heptanone, 1-(4-fluorophenyl)is often used as a flavoring agent in food products.

Valuable intermediate

The compound's unique chemical properties make it an important building block in the synthesis of other organic compounds.

Upstream product

• 592-41-6 1-hexene 
• 459-57-4 4-fluorobenzaldehyde 
• 403-43-0 4-fluorobenzoyl chloride 
• 21369-64-2 n-hexyllithium 
• 349644-07-1 (4-fluorophenyl)(pyrrolidin-1-yl)methanone 
• 459-56-3 4-fluorobenzylic alcohol 
• 462-06-6 fluorobenzene 
• 2528-61-2 Heptanoic acid chloride 

Downstream Products

• 1815-31-2 α-<4-Fluor-phenyl>-heptylamin 

Relevant academic research and scientific papers

A Fast and General Route to Ketones from Amides and Organolithium Compounds under Aerobic Conditions: Synthetic and Mechanistic Aspects

We report that the nucleophilic acyl substitution reaction of aliphatic and (hetero)aromatic amides by organolithium reagents proceeds quickly (20 s reaction time), efficiently, and chemoselectively with a broad substrate scope in the environmentally responsible cyclopentyl methyl ether, at ambient temperature and under air, to provide ketones in up to 93 % yield with an effective suppression of the notorious over-addition reaction. Detailed DFT calculations and NMR investigations support the experimental results. The described methodology was proven to be amenable to scale-up and recyclability protocols. Contrasting classical procedures carried out under inert atmospheres, this work lays the foundation for a profound paradigm shift of the reactivity of carboxylic acid amides with organolithiums, with ketones being straightforwardly obtained by simply combining the reagents under aerobic conditions and with no need of using previously modified or pre-activated amides, as recommended.

Hydroacylation of 4-[18F]fluorobenzaldehyde: A novel method for the preparation of 4′-[18F]phenylketones

To assess the potential of intermolecular hydroacylation reactions as a new fluorine-18 labeling method, model reactions of [18F]fluorobenzaldehyde with three different olefins (1-hexene (2a), allylbenzene (2b), and 3-phenoxypropene (2c)) in th

Direct conversion of benzyl alcohol to ketone by polymer-supported Rh catalyst

Benzyl alcohol reacted with 1-alkene to give the corresponding ketone by in situ generated polystyrene-based rhodium catalyst. The catalytic activity of this polymer-supported rhodium catalyst has not been reduced after reusing it four times.