84199-93-9Relevant academic research and scientific papers
Nickel-catalyzed cross-electrophile coupling of 2-chloropyridines with alkyl bromides
Everson, Daniel A.,Buonomo, Joseph A.,Weix, Daniel J.
supporting information, p. 233 - 238 (2014/02/14)
The synthesis of 2-alkylated pyridines by the nickel-catalyzed cross-coupling of two electrophiles, a 2-chloropyridine and an alkyl bromide, is described. Compared with our previously published conditions for aryl halides, this method uses a different, more rigid, bathophenanthroline ligand and is conducted at high concentration in N,N-dimethylformamide as solvent. The method displays promising functional group compatibility and the conditions are orthogonal to those for the Stille coupling.Georg Thieme Verlag Stuttgart.
