34996-89-9

Upstream product

• 107523-67-1 N-benzoyl-O-methyl-tyrosine hydroxyamide 
• 58486-86-5 4-p-Methoxybenzylidene-2-phenyl-2-imidazolin-5-one 
• 5429-22-1 4-(4-methoxybenzylidene)-2-phenyl-5(4H)-oxazolone 
• 7732-18-5 water 
• 67-56-1 methanol 
• 187836-07-3 methyl (N-benzoyl)-4'-methoxyphenylalaninate 
• 57427-78-8 (4Z)-4-(4-methoxybenzylidene)-2-phenyl-oxazolin-5-one 
• 21542-84-7 2-benzoylamino-3-(4-methoxy-phenyl)-acrylic acid 

Downstream Products

• 144754-19-8 (R)-4-methoxy-N-benzoyl-phenylalanine 
• 92265-04-8 4-(4-methoxy-benzyl)-2-phenyl-4H-oxazol-5-one 
• 7635-29-2 O-methyl tyrosine 
• 1204591-65-0 C₂₀H₂₁NO₄ 
• 1565852-67-6 4-(4-methoxybenzyl)-4-(2-(trimethylsilyl)ethynyl)-2-phenyloxazol-5(4H)-one 

Relevant academic research and scientific papers

Optimisation and synthesis of libraries derived from phenolic amino acid scaffolds

Functionalisation of a series of resin bound phenolic amino acids is described, employing Irori technology to produce multidimensional libraries. (C) 2000 Elsevier Science Ltd.

Solid phase reduction of oxazolones using BER-Ni2B-A simple synthesis of N-benzoylphenylalanines

Borohydride exchange resin (BER)-Ni2B is successfully used as a reagent for the solid phase reduction of the C-4 exocyclic double bond of oxazolones to give the N-benzoylphenylalanines and hence the corresponding amino acids.

Ring opening with kinetic resolution of azlactones by Ti-TADDOLates

The kinetic resolution of azlactones by the Lewis, acid-mediated transfer of an isopropoxide ligand from the chiral ligand sphere of Ti- TADDOLate is described. The reactions proceed with in-situ racemization of the starting material to afford highly enantiomerically enriched N-benzoyl- amino acid isopropylesters (er > 95:5 after recrystallization). The absolute configuration of the major enantiomer of N-benzoyl-phenylalanine isopropyl ester and its analogs with other aromatic substituents was shown to be (S)- (+) when the (R,R)-Ti-TADDOLate was employed. Only benzyl-substituted azlactones can be opened enantioselectively by the method described here.

Composition containing a penem or carbapenem antibiotic and the use of the same

Administration of an N-acylated amino acid in association with a penem or carbapenem antibiotic relieves or eliminates the renal problems associated with administration of the antibiotic alone. The amino acid derivative and antibiotic may be formulated together as a composition or administered separately, either simultaneously or sequentially.

Composition containing a penem or carbapenem antibiotic

Administration of an N-acylated amino acid in association with a penem or carbapenem antibiotic relieves or eliminates the renal problems associated with administration of the antibiotic alone. The amino acid derivative and antibiotic may be formulated together as a composition or administered separately, either simultaneously or sequentially. The composition may be prepared by simple mixing.

Synthesis of Acylamino Acids and Acylamino Acid Amides by Simultaneous Reduction and Hydrolysis of Unsaturated 2,4-Disubstituted 2-Imidazolin-5-ones

Twelve acylamino acids (II) and two acylamino acid amides (III) have been prepared by the simultaneous reduction and hydrolysis of unsaturated 2,4-disubstituted 2-imidazolin-5-ones (I) with a mixture of zinc dust and potassium hydroxide solution.