35026-75-6

Basic information

• Product Name: (R)-(+)-[1-(p-methoxyphenyethyl)]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
• Synonyms: (R)-(+)-[1-(p-methoxyphenyethyl)]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 35026-75-6
• Molecular Weight: 327.423
• Mol File: 35026-75-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-(+)-[1-(p-methoxyphenyethyl)]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-[1-(p-methoxyphenyethyl)]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline(35026-75-6)
• EPA Substance Registry System: (R)-(+)-[1-(p-methoxyphenyethyl)]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline(35026-75-6)

Safety Data

• Hazardous Substances Data: 35026-75-6(Hazardous Substances Data)

Upstream product

• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 1929-29-9 3-(4-methoxyphenyl)propanoic acid 
• 30002-00-7 N-(3,4-dimethoxyphenethyl)-3-(4-methoxyphenyl)propanamide 
• 30002-01-8 6,7-dimethoxy-1-(4-methoxyphenethyl)-3,4-dihydroisoquinoline 
• 1620818-54-3 N-(2-nitrophenylsulfenyl)-β-(3-hydroxy-4-methoxyphenyl)ethylamine 
• 3213-30-7 5-(2-amino-ethyl)-2-methoxy-phenol 
• 1620818-60-1 C₂₅H₂₆N₂O₅S 
• 36455-21-7 3-benzyloxy-4-methoxyphenylethylamine 

Relevant articles and documents

Total Synthesis of (-)-Melanthioidine by Copper-Mediated Cyclodimerization

An efficient asymmetric total synthesis of the dimeric macrocyclic diaryl ether phenethyltetrahydroisoquinoline alkaloid (-)-melanthiodine is reported. Key steps of the synthesis include an efficient Noyori asymmetric transfer hydrogenation to access the enantioenriched phenethyltetrahydroisoquinoline monomeric subunit and a copper-mediated cyclodimerization to form the two diaryl ether linkages with concomitant macrocyclization.

Organocatalytic enantioselective pictet-spengler reactions for the syntheses of 1-substituted 1,2,3,4-tetrahydroisoquinolines

A series of 1-substituted 1,2,3,4-tetrahydroisoquinolines was prepared from N-(o-nitrophenylsulfenyl)phenylethylamines through BINOL-phosphoric acid [(R)-TRIP]-catalyzed asymmetric Pictet-Spengler reactions. The sulfenamide moiety is crucial for the rate