30002-01-8Relevant academic research and scientific papers
Synthesis and X-ray crystallographic analysis of free base and hexafluorophosphate salts of 3,4-dihydroisoquinolines from the Bischler-Napieralski reaction
Puerto Galvis, Carlos E.,Granados, Cristian C.,Kouznetsov, Vladimir V.,Macías, Mario A.
, p. 1565 - 1572 (2021)
The Bischler-Napieralski reaction of N-phenylethyl cinnamamides was investigated in acetonitrile and 1-butyl-3-methylimidazolium hexafluorophosphate ([bmim]PF6). Strong effects on the nature of the isolated products were observed depending on the structur
Biomimetic Total Synthesis of Dysoxylum Alkaloids
Puerto Galvis, Carlos E.,Kouznetsov, Vladimir V.
, p. 15294 - 15308 (2019/11/29)
A five-step total synthesis of Dysoxylum alkaloids has been achieved using a biomimetic approach from zanthoxylamide protoalkaloids. The synthesis featured a direct amidation and a Bischler-Napieralski reaction to form the dihydroisoquinoline ring, which
Synthesis and structure activity relationship of tetrahydroisoquinoline- based potentiators of GluN2C and GluN2D containing N-Methyl-D-aspartate receptors
Santangelo Freel, Rose M.,Ogden, Kevin K.,Strong, Katie L.,Khatri, Alpa,Chepiga, Kathryn M.,Jensen, Henrik S.,Traynelis, Stephen F.,Liotta, Dennis C.
supporting information, p. 5351 - 5381 (2013/07/26)
We describe here the synthesis and evaluation of a series of tetrahydroisoquinolines that show subunit-selective potentiation of NMDA receptors containing the GluN2C or GluN2D subunits. Bischler-Napieralski conditions were employed in the key step for the
