350583-40-3

Upstream product

• 350583-28-7 1,2-benzylidene-4α,20-dihydroxy-9,10-isopropylidene-5-deoxytaxicin-I 
• 350583-27-6 1,2-benzylidene-9,10-isopropylidene-5α-acetyltaxicin-I 
• 229619-06-1 C₃₅H₅₂O₆Si 
• 350583-37-8 C₃₅H₅₄O₆Si 
• 350583-38-9 C₃₆H₅₆O₆Si 
• 229619-05-0 C₃₀H₄₂O₇ 
• 350583-36-7 C₂₉H₃₈O₆ 
• 229619-04-9 1,2-benzylidene-9,10-isopropylidene-5-deoxytaxicin-I 
• 182072-53-3 1,2-O-benzylidene-9,10-O-isopropylidene taxicine I 
• 350583-39-0 C₃₆H₅₆O₇Si 

Downstream Products

• 350583-41-4 C₅₄H₆₁NO₁₁ 

Relevant academic research and scientific papers

Semisynthesis of flexible 5,7-dideoxypaclitaxel derivatives from Taxine B

Two new 5,7-dideoxypaclitaxel derivatives with flexible C-rings have been prepared starting from Taxine B, an alkaloid isolated from the leaves of Taxus baccata. Both derivatives lack the oxetane ring present in the antitumor agent paclitaxel, but possess an oxygenated 4β-substituent as a substitute for the oxetane ring oxygen atom. These derivatives provide additional information about the importance of this oxygen atom for cytotoxic activity.