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PROPRANOLOL HYDROCHLORIDE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • (RS)-1-[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanolhydrochloride

    Cas No: 3506-09-0

  • USD $ 1.9-2.9 / Gram

  • 100 Gram

  • 1000 Metric Ton/Month

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  • 3506-09-0 Structure
  • Basic information

    1. Product Name: PROPRANOLOL HYDROCHLORIDE
    2. Synonyms: (RS)-1-[(1-METHYLETHYL)AMINO]-3-(1-NAPHTHALENYLOXY)-2-PROPANOL HYDROCHLORIDE;PROPRANOLOL HCL;(+/-)-PROPANOLOL HCL;PROPANOLOL HYDROCHLORIDE;1-(isopropylamino)-3-(1-naphthyloxy)-,hydrochloride,(+-)-2-propano;1-(ISOPROPYLAMINO)-3-(A-NAPHTHOXY)-2-PROPANOL HYDROCHLORIDE;(+)-1-(ISOPROPYLAMINO)-3-(1-NAPHTHYLOXY)-2-PROPANOL, HCL;(+/-)-1-(ISOPROPYLAMINO)-3-(1-NAPHTHYLOXY)-2-PROPANOL, HCL
    3. CAS NO:3506-09-0
    4. Molecular Formula: C16H21NO2*ClH
    5. Molecular Weight: 295.8
    6. EINECS: 206-268-7
    7. Product Categories: Adrenoceptor
    8. Mol File: 3506-09-0.mol
  • Chemical Properties

    1. Melting Point: 163-165 °C(lit.)
    2. Boiling Point: 446.1oC at 760 mmHg
    3. Flash Point: 223.6oC
    4. Appearance: white/powder
    5. Density: N/A
    6. Vapor Pressure: 9.66E-09mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: 2-8°C
    9. Solubility: H2O: 50 mg/mL, clear, colorless
    10. CAS DataBase Reference: PROPRANOLOL HYDROCHLORIDE(CAS DataBase Reference)
    11. NIST Chemistry Reference: PROPRANOLOL HYDROCHLORIDE(3506-09-0)
    12. EPA Substance Registry System: PROPRANOLOL HYDROCHLORIDE(3506-09-0)
  • Safety Data

    1. Hazard Codes: Xn
    2. Statements: 22
    3. Safety Statements: N/A
    4. RIDADR: 3249
    5. WGK Germany: 3
    6. RTECS: UB7525000
    7. F: 10
    8. HazardClass: 6.1(b)
    9. PackingGroup: III
    10. Hazardous Substances Data: 3506-09-0(Hazardous Substances Data)

3506-09-0 Usage

Uses

Adrenoceptor antagonist, anti-arrythmic

Biological Activity

β -adrenergic antagonist. See separate isomers ((R)-(+)-Propranolol hydrochloride and (S)-(-)-Propranolol hydrochloride).

Check Digit Verification of cas no

The CAS Registry Mumber 3506-09-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,5,0 and 6 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 3506-09:
(6*3)+(5*5)+(4*0)+(3*6)+(2*0)+(1*9)=70
70 % 10 = 0
So 3506-09-0 is a valid CAS Registry Number.
InChI:InChI=1/C17H23NO2.ClH/c1-13(2)10-18-11-15(19)12-20-17-9-5-7-14-6-3-4-8-16(14)17;/h3-9,13,15,18-19H,10-12H2,1-2H3;1H

3506-09-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name Propranolol hydrochloride,(RS)-1-[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanolhydrochloride

1.2 Other means of identification

Product number -
Other names dl-propranololHClbp

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:3506-09-0 SDS

3506-09-0Relevant articles and documents

Covalent Organic Frameworks with Chirality Enriched by Biomolecules for Efficient Chiral Separation

Zhang, Sainan,Zheng, Yunlong,An, Hongde,Aguila, Briana,Yang, Cheng-Xiong,Dong, Yueyue,Xie, Wei,Cheng, Peng,Zhang, Zhenjie,Chen, Yao,Ma, Shengqian

supporting information, p. 16754 - 16759 (2018/11/27)

The separation of racemic compounds is important in many fields, such as pharmacology and biology. Taking advantage of the intrinsically strong chiral environment and specific interactions featured by biomolecules, here we contribute a general strategy is developed to enrich chirality into covalent organic frameworks (COFs) by covalently immobilizing a series of biomolecules (amino acids, peptides, enzymes) into achiral COFs. Inheriting the strong chirality and specific interactions from the immobilized biomolecules, the afforded biomolecules?COFs serve as versatile and highly efficient chiral stationary phases towards various racemates in both normal and reverse phase of high-performance liquid chromatography (HPLC). The different interactions between enzyme secondary structure and racemates were revealed by surface-enhanced Raman scattering studies, accounting for the observed chiral separation capacity of enzymes?COFs.

Ultrafast chiral separations for high throughput enantiopurity analysis

Barhate, Chandan L.,Joyce, Leo A.,Makarov, Alexey A.,Zawatzky, Kerstin,Bernardoni, Frank,Schafer, Wes A.,Armstrong, Daniel W.,Welch, Christopher J.,Regalado, Erik L.

supporting information, p. 509 - 512 (2017/01/13)

Recent developments in fast chromatographic enantioseparations now make high throughput analysis of enantiopurity on the order of a few seconds achievable. Nevertheless, routine chromatographic determinations of enantiopurity to support stereochemical investigations in pharmaceutical research and development, synthetic chemistry and bioanalysis are still typically performed on the 5-20 min timescale, with many practitioners believing that sub-minute enantioseparations are not representative of the molecules encountered in day to day research. In this study we develop ultrafast chromatographic enantioseparations for a variety of pharmaceutically-related drugs and intermediates, showing that sub-minute resolutions are now possible in the vast majority of cases by both supercritical fluid chromatography (SFC) and reversed phase liquid chromatography (RP-LC). Examples are provided illustrating how such methods can be routinely developed and used for ultrafast high throughput analysis to support enantioselective synthesis investigations.

Establishment and Evaluation of the Novel Tetramethylammonium-L-Hydroxyproline Chiral Ionic Liquid Synergistic System Based on Clindamycin Phosphate for Enantioseparation by Capillary Electrophoresis

Xu, Guangfu,Du, Yingxiang,Du, Fan,Chen, Jiaquan,Yu, Tao,Zhang, Qi,Zhang, Jinjing,Du, Shuaijing,Feng, Zijie

supporting information, p. 598 - 604 (2015/08/25)

Much attention has been paid to chiral ionic liquids (ILs) in analytical chemistry, especially its application in capillary electrophoresis (CE) enantioseparation. However, the investigation of chiral ionic liquids synergistic systems based on antibiotic chiral selectors has been reported in only one article. In this work, a novel chiral ionic liquid, tetramethylammonium-L-hydroxyproline (TMA-L-Hyp), was applied for the first time in CE chiral separation to evaluate its potential synergistic effect with clindamycin phosphate (CP) as the chiral selector. As observed, significantly improved separation was obtained in this TMA-L-Hyp/CP synergistic system compared to TMA-L-Hyp or a CP single system. Several primary factors that might influence the separation were investigated, including CP concentration, TMA-L-Hyp concentration, buffer pH, types and concentrations of organic modifier, applied voltage, and capillary temperature. The best results were obtained with a 40 mM borax buffer (pH 7.6) containing 30 mM TMA-L-Hyp, 80 mM CP, and 20% (v/v) methanol, while the applied voltage and temperature were set at 20 kV and 20°C, respectively. Chirality 27:598-604, 2015.

Uridine, thymidine and inosine used as chiral stationary phases in HPLC

Zhang, Mei,Zi, Min,Wang, Bang-Jin,Yuan, Li-Ming

, p. 2226 - 2228 (2014/06/09)

In this paper, we present the first enantioseparations research using thymidine, uridine and inosine as chiral stationary phase bonded to silica gel via 3-(triethoxysilyl)propyl isocyanate in HPLC. Thymidine and uridine chiral stationary phases possess enantioseparation selectivity for alcohols, amines, ketones and carboxylic acids to some degree in normal-phase and reversed-phase mode. This work indicates that nucleoside or deoxynucleoside can be useful for the separation of enantiomers in the liquid phase as a new kind of chiral stationary phase.

Combined use of ionic liquid and hydroxypropyl-β-cyclodextrin for the enantioseparation of ten drugs by capillary electrophoresis

Cui, Yan,Ma, Xiaowei,Zhao, Min,Jiang, Zhen,Xu, Shuying,Guo, Xingjie

, p. 409 - 414 (2013/07/26)

In the present study, hydroxypropyl-β-cyclodextrin and an ionic liquid (1-ethyl-3-methylimidazolium-l-lactate) were used as additives in capillary electrophoresis for the enantioseparation of 10 analytes, including ofloxacin, propranolol hydrochloride, dioxopromethazine hydrochloride, isoprenaline hydrochloride, chlorpheniramine maleate, liarozole, tropicamide, amlodipine benzenesulfonate, brompheniramine maleate, and homatropine methylbromide. The effects of ionic liquid concentrations, salt effect, cations, and anions of ionic liquids on enantioseparation were investigated and the results proved that there was a synergistic effect between hydroxypropyl-β-cyclodextrin and the ionic liquid, and the cationic part of the ionic liquid played an important role in the increased resolution. With the developed dual system, all the enantiomers of 10 analytes were well separated in resolutions of 5.35, 1.76, 1.85, 2.48, 2.88, 1.43, 5.45, 4.35, 2.76, and 2.98, respectively. In addition, the proposed method was applied to the determination of the enantiomeric purity of S-ofloxacin after validation of the method in terms of selectivity, repeatability, linearity range, accuracy, precision, limit of detection (LOD), and limit of quality (LOQ). Chirality 25:409-414, 2013.

Aminoalcohols, III: Preparation of Enantiomerically Pure Pharmacologically Active N-Substituted β-Aminoalcohols

Noe, C. R.,Knollmueller, M.,Gaertner, P.,Fleischhacker, W.,Katikarides, E.

, p. 557 - 564 (2007/10/02)

A synthesis of N-substituted β-aminoalcohols is described starting from enantiomerically pure O-MBF- or O-MBE-protected β-aminoalcohols which can be prepared via LiAlH4 reduction of O-protected cyanohydrines. - Keywords: 1,2-Amino-alcohols, enantiomerically pure; N-Alkylation; Clorprenaline; Propranolol; Midodrine

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