35065-13-5Relevant academic research and scientific papers
Synthesis, antitubercular evaluation, molecular docking and molecular dynamics studies of 4,6-disubstituted-2-oxo-dihydropyridine-3-carbonitriles
Verma, Ruchi,Boshoff, Helena I.M.,Arora, Kriti,Bairy, Indira,Tiwari, Mradul,Bhat, Varadaraj G.,Shenoy, Gautham G.
, p. 117 - 133 (2019)
A new series of novel diphenyl ether based 2-oxo-dihydropyridine derivatives were synthesized and screened for their in vitro antimycobacterial and antibacterial activities. Most of the synthesized compounds showed significant activity against Mycobacteri
Design, synthesis and evaluation of diphenyl ether analogues as antitubercular agents
Inturi, Bharathkumar,Pujar, Gurubasavaraj V.,Purohit, Madhusudhan N.,Iyer, Viswanathan B.,G. S., Sowmya,Kulkarni, Madhuri
, p. 110571 - 110582 (2016)
We herein report the investigation of new diphenyl ethers as Mycobacterium tuberculosis enoyl-acyl carrier protein reductase (InhA) inhibitors by structure-based drug design approach. The virtual library of diphenyl ethers was designed and molecules with
In silico studies, synthesis and anticancer activity of novel diphenyl ether-based pyridine derivatives
Verma, Ruchi,Bairy, Indira,Tiwari, Mradul,Bhat, G. Varadaraj,Shenoy, G. Gautham
, p. 541 - 554 (2019)
Abstract: A series of novel 2-amino-4-(3-hydroxy-4-phenoxyphenyl)-6-(4-substituted phenyl) nicotinonitriles were synthesized and evaluated against HepG2, A-549 and Vero cell lines. Compounds 3b (IC50 16.74 ± 0.45 μM) and 3p (IC50 10.
Synthesis, biological evaluation and molecular dynamics simulation studies of novel diphenyl ethers
Bhat, Pritesh,Cinu Thomas, A.,Kar, Sidhartha S.,Khade, Amol B.,Shenoy, G. Gautham,Tiwari, Ashutosh,Tiwari, Mradul,Vandana, K. E.,Varadaraj Bhat, G.
, p. 256 - 270 (2020/03/10)
A series of novel N-(1-(3-hydroxy-4-phenoxyphenyl)-3-oxo-3-phenylpropyl)acetamides and N-(3(3-hydroxy-4phenoxyphenyl)-3-oxo-1-phenylpropyl) acetamides were designed, synthe-sized, and evaluated against HepG2, A-549, MCF-7 and Vero cell lines. Among the te
Novel diphenyl ethers: Design, docking studies, synthesis and inhibition of enoyl ACP reductase of Plasmodium falciparum and Escherichia coli
Chhibber, Manmohan,Kumar, Gyanendra,Parasuraman, Prasanna,Ramya,Surolia, Namita,Surolia, Avadhesha
, p. 8086 - 8098 (2007/10/03)
We designed some novel diphenyl ethers and determined their binding energies for Enoyl-Acyl Carrier Protein Reductase (ENR) of Plasmodium falciparum using Autodock. Out of these, we synthesized the promising compounds and tested them for their inhibitory
