350685-50-6

Basic information

• Product Name: Carbamic acid, [(1R)-1-formyl-2-(phenylmethoxy)ethyl]-, 1,1-dimethylethyl ester
• CAS NO: 350685-50-6
• Molecular Formula: C15H21NO4
• Molecular Weight: 279.336
• Mol File: 350685-50-6.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1R)-1-formyl-2-(phenylmethoxy)ethyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1R)-1-formyl-2-(phenylmethoxy)ethyl]-, 1,1-dimethylethyl ester(350685-50-6)
• EPA Substance Registry System: Carbamic acid, [(1R)-1-formyl-2-(phenylmethoxy)ethyl]-, 1,1-dimethylethyl ester(350685-50-6)

Safety Data

• Hazardous Substances Data: 350685-50-6(Hazardous Substances Data)

Upstream product

• 108149-63-9 4-hydroxymethyl-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester 
• 100-39-0 benzyl bromide 
• 1339950-10-5 (R)-tert-butyl 4-((benzyloxy)methyl)-2,2-dimethyloxazolidine-3-carboxylate 
• 67389-47-3 (R)-3-benzyloxy-2-tert-butoxycarbonyl-amino-propionic acid methyl ester 
• 47173-80-8 N-Boc-D-serine(Bzl)-OH 
• 79069-15-1 tert-butyl N-[(1S)-1-(benzyloxymethyl)-2-hydroxy-ethyl]carbamate 

Downstream Products

• 1187056-26-3 (4R)-4-(benzyloxymethyl)-5-(1-hydroxypropan-2-yl)oxazolidin-2-one 
• 1187056-25-2 (4R)-4-(benzyloxymethyl)-5-(but-3-en-2-yl)oxazolidin-2-one 
• 1187056-27-4 C₁₄H₁₇NO₄ 
• 1187056-24-1 tert-butyl (2R)-1-(benzyloxy)-3-hydroxy-4-methylhex-5-en-2-ylcarbamate 
• 882869-65-0 C₁₅H₂₂N₂O₄ 

Relevant articles and documents

DEUTERATED COMPOUNDS FOR USE IN THE TREATMENT OF CANCER

The application relates to deuterated amide derivatives of formula (I) and their use in the treatment and prophylaxis of cancer, and to compositions containing said derivatives and processes for their preparation.

Synthesis of Enantiomerically Pure 3-Substituted Piperazine-2-acetic Acid Esters as Intermediates for Library Production

The piperazine heterocycle is broadly exploited in FDA-approved drugs and biologically active compounds, but its chemical diversity is usually limited to ring nitrogen substitutions, leaving the four carbon atoms underutilized. Using an efficient six-step synthesis, chiral amino acids were transformed into 3-substituted piperazine-2-acetic acid esters as diastereomeric mixtures whose cis and trans products (dr 0.56 a? 2.2:1, respectively) could be chromatographically separated. From five amino acids (both antipodes) was obtained a complete matrix of 20 monoprotected chiral 2,3-disubstituted piperazines, each as a single absolute stereoisomer, all but one in multigram quantities. In keeping with our overall purpose of constructing more Csp3-enriched compound libraries for drug discovery, these diverse and versatile piperazines can be functionalized on either nitrogen atom, allowing them to be used as scaffolds for parallel library synthesis and as intermediates for the production of novel piperazine compounds.

A stereoselective route to cis-(2S,3R)-3-hydroxypipecolic acid and two enantiomeric cis-2-hydroxymethyl-3-hydroxypiperidine derivatives

Stereoselective routes to cis-(2S,3R)-3-hydroxypipecolic acid and two enantiomeric cis-2-hydroxymethyl-3-hydroxypiperidine derivatives from a common precursor have been developed, which featured stereocontrolled vinylation of a -chiral aldehyde and ring-closing metathesis as key steps. Georg Thieme Verlag Stuttgart. New York.